OBJECTIVES Tumor-associated macrophages (TAMs) are thought to be involved in the perineural invasion (PNI) process and to be associated with poor prognoses. The associations between TAMs, PNI, and clinicopathological features in pancreatic ductal adenocarcinomas (PDAs) remain to be elucidated. METHODS Fifty-nine PDA patients who had undergone pancreaticoduodenectomy were retrospectively exami...

BACKGROUND Perineural invasion (PNI) is the dominant pathway for local invasion in prostate cancer. To date, only few studies have investigated the molecular differences between prostate tumors with PNI and those without it. METHODS To evaluate the involvement of both microRNAs and protein-coding genes in PNI, we determined their genome-wide expression with a custom microRNA microarray and Af...

BACKGROUND Risks of perineural invasion (PNI) in T1-2 oral tongue squamous cell carcinoma (SCC) have not been specifically elucidated. METHODS Pathological features, including PNI, were re-reviewed under regular hematoxylin-eosin staining in 190 patients with T1-2 oral tongue SCC. RESULTS Tumor thickness >5 mm, PNI(+), and lymphovascular invasion (+) independently predicted lymph node invol...

OBJECTIVE To determine the relationship between perineural invasion (PNI) on prostate biopsy and radical prostatectomy (RP) outcomes in a contemporary RP series, as there is conflicting evidence on the prognostic significance of PNI in prostate needle biopsy specimens. PATIENTS AND METHODS From 2002 to 2007, 1256 men had RP by one surgeon. Multivariable logistic regression and Cox proportiona...

Objective: The prognostic significance of perineural invasion (PNI) in cervical cancer has been previously investigated with no consistent conclusion. This study aimed at determining the prognostic value of PNI in cervical cancer patients who underwent radical hysterectomy. Method: Clinical data of 413 patients with cervical cancer (stages IB-IIB) who underwent radical hysterectomy between 2009...

Objective: Systemic inflammatory parameters are predictors of poor prognosis in COVID-19 patients. This study evaluated whether the prognostic nutritional index, which was also related to nutrition risk and other inflammation-based scores, predictive in-hospital mortality Materials Methods: a retrospective cross-sectional single-center study. Based on exclusion criteria, 151 patients over 18 ye...

Abstract OBJECTIVES The prognostic nutritional index (PNI) is an indicator of systemic immune-nutritional condition and a well-known biomarker in lung cancer patients. Tumour-infiltrating lymphocytes (TILs) specific histological feature cancers, influencing individual’s immunological tumour responses. However, whether PNI can reflect patients’ prognosis through local immunity such as TIL unclea...

BACKGROUND/AIMS Pretreatment nutritional status is an important prognostic factor in patients treated with conventional cytotoxic chemotherapy. In the era of target therapies, its value is overlooked and has not been investigated. The aim of our study is to evaluate the value of nutritional status in targeted therapy. METHODS A total of 2012 patients with non-small cell lung cancer (NSCLC) we...