In India, a significant percentage of high risk births, which go upto 20%, are affected by perinatal asphyxia. Birth asphyxia is associated with deficient mental and physical development, severity of which leads to mortality. It is very important that a comprehensive quantitative study of the phenomenon be undertaken and a risk index formulated. Preventive measures can then be fciken to avert t...

Aims Cardiac dysfunction is reported after severe perinatal asphyxia. We hypothesized that maternal propofol anaesthesia during emergency caesarean section diminished cardiac injury in preterm fetuses exposed to global severe asphyxia in utero in comparison to isoflurane anesthesia. We tested if propofol decreased the activity of pro-apoptotic caspase-3 by activating the anti-apoptotic AKT kina...

Perinatal asphyxia is one of the leading causes of neonatal mortality in India. In addition to hypoxic-ischemic brain injury and neurological deficits, there is evidence of multi-system insult (l). Hepatic dysfunction is caused by redistributing cardiac output away from nonvital viscera to the heart, brain and adrenal glands (2). The present study was carried out to determine the extent of live...

INTRODUCTION The most often changes in the central nervous system (CNS) occurring as an effect of perinatal asphyxia are found to be hypoxic-ischemic encephalopathy (HIE) in term newborns, peri- (PVH) or intraventricular hemorrhages (IVH) and periventricular leukomalacia (PVL) in preterm neonates. Chronic hypoxia is considered to affect the brainstem in infants, especially nuclei of the hearing...

Prolonged or intermittent asphyxia in utero and during farrowing weakens piglets and renders them less capable of adaptation to extrauterine life. Piglets with lesser viability at birth have increased blood pCO2 and blood lactic acid concentrations and decreased blood pH. Moreover, the ability to thermoregulate during an acute cold stress is inversely related to umbilical blood lactate concentr...

Perinatal hypoxia results in neuronal and endothelial cell damage. The main purpose of this study was to investigate the correlation of soluble intercellular adhesion molecule 1 (sICAM-1) expression and peripheral blood changes in perinatal asphyxia with neuronal injury markers in low birth weight (LBW) neonates. We compared the concentrations of serum sICAM-1, neuron-specific enolase (NSE) and...

UNLABELLED Acute kidney injury (AKI) is a common consequence of perinatal asphyxia reported in 30 to 70% cases. We present 4 full-term neonates with oliguric/anuric AKI caused by perinatal asphyxia requiring renal replacement therapy (RRT) and their long-term outcomes. Patient No. 1 was dialyzed for 12 days (continuous ambulatory peritoneal dialysis (CAPD)/continuous venovenous hemodiafiltratio...

Objective: To evaluate the incidence, etiologies, clinical features and EEG findings of seizures among the neonates admitted to one medical center. Method: We retrospectively reviewed the medical records of neonates who were diagnosed to have neonatal seizure at the Neonatal Intensive Care Unit (NICU) of one medical center in Taiwan from January to December 2015. The clinical pictures, laborato...

CONTEXT AND OBJECTIVE Knowledge of risk factors associated with child development disorders is essential for delivering high-quality childcare. The objective here was to evaluate the relationships between risk factors and occurrences of developmental abnormalities among children attended at a reference clinic for children at risk of developmental abnormalities. DESIGN AND SETTING Retrospectiv...

I have presented the material in three sections, the first concerns the antenatal events leading to foetal anoxia, the second deals with the management of labour, and the third discusses methods of treatment which may be applicable in domiciliary midwifery. I have quoted fairly extensively from the National Perinatal Mortality Survey (1961) carried out in 1958 under the auspices of the National...