نتایج جستجو برای: perivascular space
تعداد نتایج: 500242 فیلتر نتایج به سال:
Perivascular adipose tissue AT is a critical regulator of vascular function, which until recently has been greatly overlooked. Virtually all arteries are surrounded by a significant amount of perivascular adipose tissue, which has long been considered to serve primarily a supportive, mechanical purpose. Recent studies show that both visceral and perivascular fat is a very active endocrine and p...
Virchow-Robin spaces (VRS) are perivascular spaces surrounding the perforating cerebral arteries or arterioles.1,2 They distribute throughout the subarachnoid space to the brain parenchyma. Solutes from the brain parenchyma and lymphatics are drained into VRS, but VRS themselves do not have direct communication with the subarachnoid space.3 Dilated VRS (dVRS) are easily detectable by magnetic r...
Cerebral amyloid angiopathy (CAA) affects both leptomeningeal and parenchymal blood vessels and is common in Alzheimer's disease (AD). In some vessels, CAA is accompanied by localized neuritic dystrophy around the affected blood vessel. The aim of this study was to assess the distribution and severity of perivascular neuritic dystrophy in primary visual and visual association cortices. The seve...
UNLABELLED During collateral artery growth, monocytes adhere to the endothelium and secrete cytokines from the perivascular space promoting arteriogenesis. Recently, the endothelial glycocalyx has been shown to modulate leucocyte infiltration in atherogenic regions. The role of this endothelial surface coating in arteriogenesis, however, has not been investigated so far. We now report that loca...
Cerebral small vessel disease (CSVD) is the most common vascular cause of cognitive impairment, which refers to a group of ischemic and hemorrhagic changes that mainly affect the small arteries and arterioles. Features seen on neuroimaging include white matter hyperintensities, lacunar infarction, cerebral microbleed and enlarged perivascular space, which can be assessed by both quantitative an...
BACKGROUND Heparin inhibits vascular smooth muscle cell proliferation in tissue culture and limits neointimal hyperplasia after experimental arterial injury but has been ineffective in reducing clinical restenosis. We examined how this discrepancy might reflect suboptimal drug-tissue interactions and/or differences in the vascular response to injury. METHODS AND RESULTS Intravenous infusion w...
The perivascular implantation of tissue-engineered endothelial cells around injured arteries offers an opportunity to study fundamental vascular physiology as well as restore and improve tissue function. Cell source is an important issue because the ability to implant either xenogeneic or allogeneic cells would greatly enhance the clinical applications of tissue-engineered grafts. We investigat...
Background. Heparin inhibits vascular smooth muscle cell proliferation in tissue culture and limits neointimal hyperplasia after experimental arterial injury but has been ineffective in reducing clinical restenosis. We examined how this discrepancy might reflect suboptimal drug-tissue interactions and/or differences in the vascular response to injury. Methods and Results. Intravenous infusion w...
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