The mammalian target of rapamycin complex 2 (mTORC2) contains the essential protein RICTOR and is activated by growth factors. mTORC2 in adipose tissue contributes to the regulation of glucose and lipid metabolism. In the perivascular adipose tissue, mTORC2 ensures normal vascular reactivity by controlling expression of inflammatory molecules. To assess whether RICTOR/mTORC2 contributes to bloo...

PVAT (perivascular adipose tissue) has recently been recognized as a novel factor in vascular biology, with implications in the pathophysiology of cardiovascular disease. Composed mainly of adipocytes, PVAT releases a wide range of biologically active molecules that modulate vascular smooth muscle cell contraction, proliferation and migration. PVAT exerts an anti-contractile effect in various v...

Citation: da Costa RM, Silva JFd, Alves JV, Dias TB, Rassi DM, Garcia LV, Lobato NdS and Tostes RC (2018) Increased O-GlcNAcylation of Endothelial Nitric Oxide Synthase Compromises the Anti-contractile Properties of Perivascular Adipose Tissue in Metabolic Syndrome. Front. Physiol. 9:341. doi: 10.3389/fphys.2018.00341 Increased O-GlcNAcylation of Endothelial Nitric Oxide Synthase Compromises th...

Introduction: Cutaneous leishmaniasis (CL) is a parasitic skin infection which can be debilitating. This study was performed to determine the vascular changes in the histopathology of CL. Methods: Thirty-seven patients with CL were included in a prospective study. A 4 mm punch biopsy was obtained from the border of the lesion. After histopathologic processing and H&E staining, it was reviewed ...

INTRODUCTION The aim of this study was to investigate the effect of erythropoietin on vascular contractility using an in vitro model of hypoxia replicating the hypoxic environment of blood vessels and surrounding adipose tissue in obesity. METHODS AND RESULTS Pharmacological in vitro studies were carried out on small mesenteric arterial segments from male Wistar rats with and without perivasc...

tendon never restores the complete biological and mechanical properties after healing. bone marrow and recently adipose tissue have been used as the sources of mesenchymal stem cells, which have been proven to enhance tendon healing. stromal vascular fraction (svf), derived from adipose tissue by an enzymatic digestion, represents an alternative source of multipotent cells, which undergo differ...

Adipose tissue is commonly categorized into three types with distinct functions, phenotypes, and anatomical localizations. White adipose tissue (WAT) is the major energy store; the largest depots of WAT are found in subcutaneous or intravisceral sites. Brown adipose tissue (BAT) is responsible for energy dissipation during cold-exposure (i.e., non-shivering thermogenesis) and is primarily locat...

BACKGROUND Although inflammation within adipose tissues is known to play a role in metabolic syndrome, the causative connection between inflamed adipose tissue and atherosclerosis is not fully understood. In the present study, we examined the direct effects of adipose tissue on macro-vascular inflammation using intravital microscopic analysis of the femoral artery after adipose tissue transplan...

OBJECTIVE Obesity and hypertension are comorbid in epidemic proportion, yet their biological connection is largely a mystery. The peptide chemerin is a candidate for connecting fat deposits around the blood vessel (perivascular adipose tissue) to arterial contraction. We presently tested the hypothesis that chemerin is expressed in perivascular adipose tissue and is vasoactive, supporting the e...