Satellite-based and reanalysis precipitation products have experienced increasing popularity in agricultural, hydrological meteorological applications, but their accuracy is still uncertain different areas. In this study, six frequently used high-resolution daily products, including Climate Hazards Group InfraRed Precipitation with Station data (CHIRPS), Global Satellite Mapping of (GSMaP), Int...

OBJECTIVE The integration of the Common Drug Review (CDR) was a substantial change for Canada's public drug plans. Detailed comparisons of time-to-listing and proportion of medications covered by the province of Alberta's drug plans within the context of the CDR process have not been rigorously conducted. METHODS New drugs approved by Health Canada were identified five years prior to the CDR'...

A synthetic phage-displayed antibody repertoire was constructed with equivalent chemical diversity in the third complementarity-determining regions of the heavy (CDR-H3) and light (CDR-L3) chains, which contrasts with natural antibodies in which CDR-H3 is much more diverse than CDR-L3 due to the genetic mechanisms that generate antibody encoding genes. Surprisingly, the synthetic repertoire yie...

BACKGROUND/AIMS We investigated quantitative/qualitative changes of instrumental activities of daily living (IADL) in people with a Clinical Dementia Rating (CDR) of 0.5. METHODS IADLs were evaluated in older residents: CDR of 0 (healthy) and CDR 0.5 (questionable/very mild dementia). The subjects with CDR 0.5 were divided into 2 types: the very mild Alzheimer's disease (vmAD) type and the ot...

Background: DNA molecule of the eukaryotic cells is found in the form of a nucleoprotein complex named chromatin. Two epigenetic modifications are critical for transcriptional control of genes, including acetylation and DNA methylation. Hypermethylation of tumor suppressor genes is catalyzed by various DNA methyltransferase enzymes (DNMTs), including DNMT1, DNMT2, and DNMT3. The most well chara...

Satellite precipitation products are a means of estimating rainfall, particularly in areas that are sparsely equipped with rain gauges. The Guiana Shield is a region vulnerable to high water episodes. Flood risk is enhanced by the concentration of population living along the main rivers. A good understanding of the regional hydro-climatic regime, as well as an accurate estimation of precipitati...

Remotely sensed precipitation estimates (RSPEs) play an essential role in monitoring drought, especially ungauged or sparsely gauged areas. In this study, we evaluated the ability of three popular long-term RSPEs (PERSIANN, CHIRPS, and MSWEP) capturing meteorological drought variations over 10 first-level water resource basins China, based on standardized index (SPI). Drought events were identi...

Antibodies are used extensively in medical and biological research. Their complementarity determining regions (CDRs) define the majority of their antigen binding functionality. CDR structures have been intensively studied and classified (canonical structures). Here we show that CDR structure prediction is no different from the standard loop structure prediction problem and predict them without ...

Given the importance of cross-disciplinary research (CDR), facilitating CDR effectiveness is a priority for many institutions and funding agencies. There are a number of CDR types, however, and the effectiveness of facilitation efforts will require sensitivity to that diversity. This article presents a method characterizing a spectrum of CDR designed to inform facilitation efforts that relies o...