BACKGROUND To assess persistence rates of biologic agents for the treatment of rheumatoid arthritis in Japan. METHODS Based on Japanese claims data of 16,214 patients between 2012 and 2014, 6-, 12-, and 18-month persistence rates of different biologic agents were calculated. Determinants of persistence were assessed by means of a multivariate Cox proportional hazard model controlling for age,...

Multidimensional persistence modules do not admit a concise representation analogous to that provided by persistence diagrams for real-valued functions. However, there is no obstruction for multidimensional persistent Betti numbers to admit one. Therefore, it is reasonable to look for a generalization of persistence diagrams concerning those properties that are related only to persistent Betti ...

We revisit the problem of local persistence in directed percolation, reporting improved estimates of the persistence exponent in 1+1 dimensions, discovering strong corrections to scaling in higher dimensions, and investigating the mean field limit. Moreover, we examine a graded persistence probability that a site does not flip more than m times and demonstrate how local persistence can be studi...

We describe a new methodology for studying persistence of topological features across a family of spaces or point-cloud data sets, called zigzag persistence. Building on classical results about quiver representations, zigzag persistence generalises the highly successful theory of persistent homology and addresses several situations which are not covered by that theory. In this paper we develop ...

A previously reported form of microbial persistence whereby large populations of tubercle bacilli can be made to "vanish" uniformly from the tissues of mice has been shown to occur generally throughout each group of animals subjected to the experimental procedure; it does not reflect the eradication of the bacilli in the majority of animals with their persistence and ultimate revival in only a ...

Dichev and Tang (2008) (this issue) document the incremental predictive power of past earnings volatility for the persistence of current earnings. We revisit their findings by allowing for several theoretically motivated factors (firm size, earnings growth, and the extent of managerial accounting discretion as detected by abnormal accruals) in order to verify the robustness of this effect. We a...

Conventional wisdom in political economy warns that once an economic policy is introduced, it is likely to persist. Even when its original rationale is no longer applicable or has been proven invalid, a policy will prove hard to remove. Empirical support for this position abounds. In both developed and developing countries, many policies appear remarkably resilient. In the United States, farm p...

background: neck and shoulder pains are the prevalent complaints among computer office workers. the purpose of this study was to assess the relationship of somatization tendency, expectation of pain, mental health and beliefs about causation of pain with persistence of neck/shoulder pains among computer office workers. methods: this research is a kind of prospective cohort study with 1‑year fol...

background: laps is one of the challenges in the treatment of opioid dependency that cause relapse. the purpose of this study was to determine the effectiveness of behavioral group therapy and cognitive-behavioral group therapy on the laps rate and persistence in the treatment of patients with opioid dependency under the treatment of mmt. methods: in a quasi-experimental study, 66 patients were...

This paper presents a pattern for generating persistence methods in runtime, using the Java API Reflection, with high levels of maintainability and reusability.