| Metagenomic studies have shown that antibiotic resistance genes are ubiquitous in the environment, which has led to the suggestion that there is a high risk that these genes will spread to bacteria that cause human infections. If this is true, estimating the real risk of dissemination of resistance genes from environmental reservoirs to human pathogens is therefore very difficult. In this Opi...

The positional cloning of the gene responsible for cystic fibrosis (CF) was the important first step in understanding the basic defect and pathophysiology of the disease. This study aims to provide a historical account of key developments as well as factors that contributed to the cystic fibrosis transmembrane conductance regulator (CFTR) gene identification work. A redefined gene structure bas...

ease. Nat Genet 38: 21–23, 2006 16. Nishio S, Tian X, Gallagher AR, Yu Z, Patel V, Igarashi P, Somlo S: Loss of oriented cell division does not initiate cyst formation. J Am Soc Nephrol 21: 295–302, 2010 17. Karner C, Wharton KA Jr, Carroll TJ: Planar cell polarity and vertebrate organogenesis. Semin Cell Dev Biol 17: 194–203, 2006 18. Karner CM, Chirumamilla R, Aoki S, Igarashi P, Wallingford ...

Erratum: “Unsafe Harbor? Elevated Blood Lead Levels in Refugee Children” A passage in the June 2013 News article “Unsafe Harbor? Elevated Blood Lead Levels in Refugee Children” [Environ Health Perspect 121:A190–A195 (2013)] attributed provisions of the Lead-Safe Housing Rule to the Lead Disclosure Rule, and certain details of both rules were omitted or unclear. The article also credited the sta...

In the original online version of “Outdoor Particulate Matter Exposure and Lung Cancer: A Systematic Review and Meta-Analysis” by Hamra et al. [Environ Health Perspect 122:906–911 (2014); http://dx.doi.org/10.1289/ehp.1408092], there were several errors. In Table 1, the number of events for Krewski et al. (2009; United States) and for Beelen et al. (2008; Netherlands) should have been “9,788 (m...

n engl j med 372;12 nejm.org march 19, 2015 1181 2. Chambaere K, Bilsen J, Cohen J, Onwuteaka-Philipsen BD, Mortier F, Deliens L. Trends in medical end-of-life decision making in Flanders, Belgium 1998-2001-2007. Med Decis Making 2011;31:500-10. 3. Belgian Official Collection of the Laws. The Belgian Act on Euthanasia of May 28th 2002. Ethical Perspect 2002;9: 182-8. 4. Onwuteaka-Philipsen BD, ...

Makaverich et al. [Environ Health Perspect 103:574-581 (1995)] reported that the uterotrophic activity of the phytoestrogen coumestrol in the immature ovariectomized rat was atypical in that it was not associated with increased uterine hyperplasia and DNA content. We previously reported that coumestrol gave a typical estradiol-type uterotrophic response in the immature intact rat, yielding incr...

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