OBJECTIVE 1) To evaluate whether peripheral blood mononuclear cells (PBMCs) from type 2 diabetic patients present an impairment of phagocytic activity; 2) To determine whether the eventual impairment in phagocytic activity is related to glycemic control and can be reversed by improving blood glucose levels. METHODS 21 type 2 diabetic patients and 21 healthy volunteers were prospectively recru...

Objective: to study the effects of GHK peptide and its structure analogues on mechanisms innate immunity lipid peroxidation in wound. Materials methods. The experiments were performed 70 male Wistar rats. skin wound was modeled by applying a full-layer with an area 250 mm2 animal's back. peptides Gly-His-Lys (GHK), D-Ala-Gly-His-Lys (D-Ala-GHK), Gly-His-Lys-D-Ala (GHK-D-Ala) used doses 0.5 μg/k...

Hemocytes in the circulation and kidney islets, as well as their phagocytic responses to microorganisms and fluorescent beads, have been studied in Pomacea canaliculata, using flow cytometry, light microscopy (including confocal laser scanning microscopy) and transmission electron microscopy (TEM). Three circulating hemocyte types (hyalinocytes, agranulocytes and granulocytes) were distinguishe...

Antibody-dependent cell-mediated cytotoxicity (ADCC) by peripheral blood mononuclear cells in patients with Sj6grcn's syndrome (SjS) was estimated with special reference te differentiation from phagocytic activity caused by phagocytes. There was no significant difference in ADCC activity of peripheral blood ITmphocytes (phagocyte-depleted lymphocyte fraction) between patients with SjS and norma...

Invasive aspergillosis (IA) is a severe infection that commonly occurs in immunocompromised patients after hematopoietic stem cell transplantation (HSCT). The present study explores the effect of Aspergillus fumigatus diffusates (AfDs) on phagocytic function and superoxide anion (O2(-)) burst levels in polymorphonuclear neutrophils (PMNs) from post-HSCT patients. A. fumigatus conidia with or wi...

Microglia are the principle immune effector and phagocytic cells in the CNS. These cells are associated with fibrillar -amyloid (fA )containing plaques found in the brains of Alzheimer’s disease (AD) patients. The plaque-associated microglia undergo a phenotypic conversion into an activated phenotype and are responsible for the development of a focal inflammatory response that exacerbates and a...

Evidence for a developmental relationship between B cells and macrophages has led to the hypothesis that B cells evolved from a phagocytic predecessor. The recent identification of phagocytic IgM+ cells in fishes and amphibians supports this hypothesis, but raises the question of when, evolutionarily, was phagocytic capacity lost in B cells? To address this, leucocytes were isolated from red-ea...

Rotaviruses and reoviruses are involved in human and animal diseases. It is known that both viruses penetrate the gastrointestinal tract but their interaction with phagocytic cells is unknown. To study this interaction, peritoneal resident phagocytic cells were used and rotavirus and reovirus replication in peritoneal phagocytic cells was observed. However, rotavirus replication in these cells ...