Background: Repeated blood transfusions lead to an accumulation of iron that exceeds the body's storage capacity. Free is able catalyze formation hydroxyl radicals cause oxidative damage and cell death. The use chelating medicines for chelation therapy limited by side effects. Mangiferin a natural bioactive compound with antioxidant activity. Mahkota dewa plant native Indonesia contains mangife...

Phaleria macrocarpa (Scheff.) Boerl., an evergreen tree is found in Indonesia, Malaysia and Oceania, explicitly Northern Territory of Australia Papua New Guinea. The fruits are traditionally used to treat various ailments including diabetes, psoriasis, looseness the bowels, skin inflammation, malignancy, kidney, liver heart sicknesses. However, date, no comprehensive study investigating its tox...

Abstract Funding Acknowledgements Type of funding sources: None. Background Phaleria macrocarpa fruit extract was reported in decreasing the low-density lipoprotein cholesterol (LDL-C) level as well increasing high-density (HDL-C) animal studies. Currently, proprotein convertase subtilisin/kexin type 9 (PCSK-9) has become a novel target for lipid modification, it enhances degradation LDL-C rece...

Godmania macrocarpa Hemsley, a deciduous tree characteristic of fire protected areas of the savanna region of central Venezuela, was more drought tolerant, allocated more N to leaves and had consistently higher photosynthetic rates than Curatella americana L., a ubiquitous species growing successfully within the grasslands of tropical American savannas. Godmania macrocarpa maintained higher lea...