نتایج جستجو برای: pharmaceutical active ingredient

تعداد نتایج: 521346  

2017
X Zhang J Duan F Kesisoglou J Novakovic GL Amidon M Jamei V Lukacova T Eissing E Tsakalozou L Zhao R Lionberger

On May 19, 2016, the US Food and Drug Administration (FDA) hosted a public workshop, entitled "Mechanistic Oral Absorption Modeling and Simulation for Formulation Development and Bioequivalence Evaluation." The topic of mechanistic oral absorption modeling, which is one of the major applications of physiologically based pharmacokinetic (PBPK) modeling and simulation, focuses on predicting oral ...

2013
M. Molloy E. B. Martin

This paper describes the application of batch trajectory alignment, outlier detection, and multiblock multiway principal component analysis (MPCA) to data from an industrial active pharmaceutical ingredient manufacturing process. The process data routinely collected from historical batches, including temperatures, pressures, and controller outputs, has been used to improve process operation and...

صادقی, محمدصالح , محمدپور, مهرداد ,

Eyes and the vision system allow the human being to receive information from the environment to the extent that 90% of the man’s information is acquired through observation, thus health and correct function of this organ have always been important. Diseases threatening vision such as Acute Macular Degeneration and Diabetic Retinopathy deprive millions of people of seeing every year while acce...

Journal: :Journal of chromatographic science 2006
Peter Sajonz Yan Wu Theresa K Natishan Neil T McGachy David Detora

A sensitive high-performance liquid chromatography (HPLC) impurity profile method for the antibiotic ertapenem is developed and subsequently validated. The method utilizes an Inertsil phenyl column at ambient temperature, gradient elution with aqueous sodium phosphate buffer at pH 8, and acetonitrile as the mobile phase. The linearity, method precision, method ruggedness, limit of quantitation,...

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