Not surprisingly, the wide range of effective medicinal agents available today is one of the greatest scientific achievements. Regardless of the advancements in effectiveness and safety of the medicines embedded in dosage forms, the pharmaceutical concept of the latter is growing to be ever more eminent (Adibkia et al., 2011). Following on from recent advancements, in a time of increased consid...

In pharmaceutical bioanalysis, researchers develop and run various assays to quantitate drugs, pharmaceutical candidates, and their metabolites in biological fluids such as serum and plasma. The data resulting from these assays are used to help determine the pharmacodynamic and pharmacokinetic properties as well as the toxic and therapeutic concentrations of existing and emerging pharmaceutical...

Pharmaceutical co-crystal formation represents a straightforward way to dramatically influence the solid-state properties of a drug substance, particularly its solubility and hence bioavailability. This short review summarises this highly topical field, covering why the topic is of interest in pharmaceutical formulation, the definitions and practical scope of co-crystals, co-crystal preparation...

analogues is true as exemplified by the studies focused upon the use of sugar conjugation: glycosylated compounds can greatly enhance drug solubility (upto >2 folds) and enhance uptake in vitro [7]. As the motive in various modifications of flavonoids is to increase the stability and biological activity, and most of the glycosylated products showed only the increase in solubility and lack of pr...

When using shear testing to determine wall friction of pharmaceutical particulate systems, it is crucial to measure at the correct wall normal stress. By comparing data obtained at a wall normal stress of 1000 to 200 Pa, the effect of the applied stress on the accuracy and precision of the method was assessed. INTRODUCTION When powder flows under gravity from a hopper, it follows one of two pat...

Korhonen, M., 2003. Rheological properties of pharmaceutical creams containing sorbitan fatty acid ester surfactants. ISBN 952-91-6585-4 (paperback) ISBN 952-10-1476-8 (PDF) The main purpose of the present study was to gain understanding about the rheological (elastic, viscoelastic and viscous) properties of pharmaceutical creams containing sorbitan fatty acid ester surfactants (sorbitan monola...