Genetic polymorphisms in the genes that encode drug-metabolizing enzymes are implicated in the inter-individual variability in the pharmacokinetics and pharmaco-dynamics of antiepileptic drugs (AEDs). However, the clinical impact of these polymorphisms on AED therapy still remains controversial. The defective alleles of cytochrome P450 (CYP) 2C9 and/or CYP2C19 could affect not only the pharmaco...

background: the aim of this study was to propose a new stochastic model to study the time course of ethanol elimination in human bodies. methods: the times and amount of alcohol ingested are assumed to be random in controllable intervals. constant elimination rate follows zero order kinetics and is replaced by first order kinetics when the effects of alcohol increase due to alcohol ingestion. s...

This review presents the clinical pharmacokinetics of the marketed therapeutic monoclonal antibodies used in oncology. Aspects regarding absorption, tissue distribution, elimination as well as factors influencing pharmacokinetics, pharmacodynamics and kinetic interactions are also discussed.

The review presents modern studies the effect of genetic polymorphisms on efficienty and safety therapy with new oral anticoagulants. Hepatic carboxylesterase encoded by CES1 gene P-glycoprotein ABCB1 affect dabigatran pharmacokinetics. role glucuronidation enzymes (UGT2B15, UGT1A9, UGT2B7) involved in active metabolism is poorly understood. An increase peak apixaban concentration was noted pat...

The biological properties of therapeutic peptides, such as their pharmacokinetics and pharmacodynamics, are correlated with structure aggregation properties. Herein, we studied the a peptide (CIGB-814), currently in phase 2 clinical trial, for treatment rheumatoid arthritis over wide range concentrations (µM–mM). We applied spectroscopic techniques (fluorescence, circular dichroism, resonance, ...

The microdosing strategy allows for early assessment of human pharmacokinetics of new chemical entities using more limited safety assessment requirements than those requisite for a conventional phase I program. The current choice for evaluating microdosing is accelerator mass spectrometry (AMS) due to its ultrasensitivity for detecting radiotracers. However, the AMS technique is still expensive...

 The aim of this study was to investigate the pharmacokinetic profiles of baicalin, wogonoside, baicalein and wogonin after oral administration of pure baicalin, Radix scutellariae and Scutellariae-Paeoniae couple extracts were administered and the pharmacokinetics profiles were compared between normal and ulcerative colitis rats. The plasma concentrations of the four flavonoids were determined...

This study was designed to evaluate pharmacokinetics of sulphadimidine   in cockerels fed on subclinical dose of arsenic (100 ppm) in diet and to determine the protective efficacy following simultaneous dietary medication with Piper longum (pipli)   (100 ppm) in a 12-week feeding trial. Pharmacokinetic parameters were determined after single i.v. dose (50 mg/kg) of sulphadimidine ...

a simple and reproducible hplc method with spectrophotometric detection was developed for determination of rivastigmine in human plasma. liquid-liquid extraction of rivastigmine and donepezil (as internal standard) from plasma samples was performed with 1-butanol/n-hexane (2:98 v/v) in alkaline condition followed by back-extraction into diluted acetic acid. chromatography was carried out using ...

The metabolism and pharmacokinetics of gefitinib (Iressa®, N-(3-chloro-4-fluorophenyl)-7-methoxy-6-(3-morpholino-propoxy)quinazolin-4-amine), a selective thymidylate kinase inhibitor for the epider...