Current guidelines recommend inhaled pharmacologic therapy as the preferred route of administration for treating COPD. Bronchodilators (β2-agonists and antimuscarinics) are the mainstay of pharmacologic therapy in patients with COPD, with long-acting agents recommended for patients with moderate to severe symptoms or those who are at a higher risk for COPD exacerbations. Dry powder inhalers and...

OBJECTIVE To evaluate the implementation of a neonatal pain and sedation protocol at 2 ICUs. METHODS The intervention started with the evaluation of local practice, problems, and staff satisfaction. We then developed and implemented the Vienna Protocol for Neonatal Pain and Sedation. The protocol included well-defined strategies for both nonpharmacologic and pharmacologic interventions based ...

Abstract Purpose of review The present article will describe the unique factors in COVID-19 patients that predispose these individuals to develop mucormycosis with emphasis placed on prevention and treatment COVID-19-associated (CAM). Recent findings Viral specific factors, pre-existing diabetes mellitus, treatments combine facilitate development mucormycosis. There appears be a gross overutili...

Aggressive diuretic therapy in a patient who is hospitalized for acute decompensated heart failure often leads to progressive renal dysfunction despite persistent congestion. The underlying mechanisms of this so-called acute cardiorenal syndrome are complex and not fully understood.1,2 As initial therapy in this setting, ultrafiltration as compared with diuretic therapy may result in a higher r...