In phenylketonuria (PKU), natural protein tolerance is defined as the maximum intake maintaining a blood phenylalanine (Phe) concentration within target therapeutic range. Tolerance affected by several factors, and it may differ throughout person’s lifespan. Data on lifelong Phe/natural are limited mostly reported in studies with low subject numbers. This systematic review aimed to investigate ...

L-phenylalanine (Phe), an essential amino acid, is necessary for the synthesis of proteins such as catecholamine and melanin, also precursor acid L-tyrosine (Tyr). In this paper, optimized structures Phe, were calculated by using semi-empirical models AM1, PM3 MNDO; Density Functional (DFT) at B3LYP Hartreefock methods (HF) with 6-311++G (d,p) level. The energies geometric parameters Kaempferol...

Developing Antiviral Coatings In article number 2202161, Tan Hu, Michaela Kaganovich, Meital Reches, and colleagues describe the self-assembly of two extremely short peptides, DOPA-Phe DOPA-Phe(4F), into spherical nanoparticles with excellent antiviral activity. When applied on a surface by drop-casting, these peptide assemblies form transparent coating that deactivate both DNA- RNA-based virus...

BACKGROUND Reducing environmental stress imposed upon gametes and embryos in the IVF laboratory is crucial in optimizing culture conditions and development. One environmental parameter of particular importance is external pH (pHe) of culture media. An optimal pHe has not been identified. METHODS Electronic searches were performed using keywords focused on pH and the embryo using PUBMED throug...

This study discusses the design of plate type heat exchangers (PHE). Conventional have many drawbacks, including difficult maintenance, high cost, and increased area usage. In contrast, a number benefits over traditional exchangers. Because liquid spreads across plate, PHE has bigger surface area. The explains exchanger, material, chevron angle, gasket material since allows for faster transmiss...

We have demonstrated that the S'(1) and S'(2) subsites of human tissue kallikrein (hK1) play determinant roles in the recognition and hydrolysis of substrates. The presence of serine at position P'(1) and arginine at P'(2) resulted in the best substrate, Abz-Ala-Ile-Lys-Phe-Phe-Ser-Arg-Gln-EDDnp, which was derived from the kallistatin reactive-centre loop sequence and quencher groups o-aminoben...

Reducing phenanthrene (PHE) in the environment is critical to ecosystem and human health. Biodegradation, biosorption, and the trans-membrane transport mechanism of PHE by a novel strain, Massilia sp. WF1, and an extensively researched model fungus, Phanerochaete chrysosporium were investigated in aqueous solutions. Results showed that the PHE residual concentration decreased with incubation ti...

Magnetic resonance imaging studies in patients with phenylketonuria (PKU) revealed white matter alterations that correlated to most recent blood phenylalanine (Phe) concentrations as well as to brain Phe concentrations measured by magnetic resonance spectroscopy. The clinical significance of these changes is unknown. Magnetic resonance imaging data thus have no impact on therapeutic recommendat...

Reducing the CP level of the diet allows for a reduction in N excretion without limiting performance as long as the amino acid (AA) requirements are covered. The availability of crystalline AA has permitted for a considerable reduction in the CP level of diets, practically used in pig nutrition. The adoption of low CP diets and the extent to which the CP content can be reduced further depends o...

Premarital health examination (PHE) is ideally to prevent sexually-transmitted diseases (STD) within a couple; to detect reproductive problems or hereditary illness which may pass to offspring; and to provide counseling on family planning and genetic health. However, little is known about the implementation of PHE program. We conducted a selfadministered questionnaire survey to participants who...