reaction between aromatic aldehydes and 3–methyl-1-phenyl-2-pyrazoline-5-one catalyzed by nano-sio2/hclo4 in water under reflux provided a simple and efficient route for the synthesis of 4-((5-hydroxy-3-methyl-1-phenyl-1h-pyrazol-4-yl)(aryl)methyl)-3-methyl-1-phenyl-1h-pyrazol-5-ol derivatives in high yields.

The title compound, C(15)H(17)NTe, is a heteroleptic Te, N-bidentate ligand having a short Te⋯N contact [2.8079 (16) Å] involving a secondary bonding inter-action between the amino N and Te(II) atoms. The Te-C bond [2.136 (2) Å] trans to the amino group is slightly elongated compared to the other Te-C bond [2.1242 (18) Å] due to the hypervalent inter-action. The bond angle for the trans N-Te-C ...

Quantum chemical (MNDo)caleulations have beenused toelucidate the molecular properties and structure - activity relationships of dihydropyridine (DHP) type calcium antagonists. There is a good corielation between the net atomic charges on various atoms of the 4 - phenyl ring of dihydropyridines and pharmacological activity. .Also, activity decreases with increasing free rotation of the phen...

reaction of 5-phenyl tetrazole with ethyl chloroacetate to form ethyl (5-phenyl-1h-tetrazol-1-yl) acetate (1). compound 1 react with hydrazine hydrate in ethanol yield 2-(5-phenyl-1h-tetrazol-1-yl) acetohydrazide (2). the condensation of (2) with various aldehydes yield the corresponding substituted n'-[-arylidene]-2-(5-phenyl-1h-tetrazol-1-yl) acetohydrazide (3a- j). the compounds obtaine...

a group of 1,3-biarylhydrazide derivatives possessing a cox-2 azido pharmacophore at the para- position of the c-1 phenyl ring in conjunction with a n-3 phenyl or substituted-phenyl ring (4-f,4-cl,4-ome) were designed and synthesized based on nucleophilic substitution reaction. a molecular modelling study of these compounds showed that the designed molecules were well bound with the active site...

a new type of magnetically-recoverable catalyst was synthesized by the immobilization of h3pw12o40 on the surface of silica-encapsulated -fe2o3 nanoparticles. a series of novel 1,3,5-triaryl pyrazoline derivatives has been synthesized by the reaction of chalcone and phenylhydrazine in the presence of the -fe2o3@sio2-pw12nanoparticles,  in high yields. the structures of compounds obtained were...

We herein aimed to evaluate the neuroprotective effects of resveratrol on a mouse model Parkinson’s disease and explore whether Wnt/beta-catenin signaling pathway was involved. Thirty male C57 black 6 mice were randomly divided into control group, group (1-methyl-4-phenyl-1,2,3,6- tetrahydropyridine) treatment (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine resveratrol) (n=10). The groups intrape...

This article presents the results of clinical and laboratory studies on examination sooty Karakul sheep. farming is one main branches animal husbandry, today some 6 million sheep are raised in desert semi-desert pastures Republic. The productivity most rangelands these areas low, this figure largely dependent atmospheric precipitation. In addition, global problem warming causing a sharp drop Pa...

The relationship between the dose of intravenously administered streptozotocin (a N-nitroso derivative of glucosamine) and the diabetogenic response has been explored by use of the following indices of diabetogenic action: serum glucose, urine volume, and glycosuria, ketonuria, serum immunoreactive insulin (IRI), and pancreatic IRI content. Diabetogenic activity could be demonstrated between th...

PURPOSE Nausea and vomiting during pregnancy (NVP) can create a significant clinical, psychological, and economic burden for patients, health care providers, and payers. The purpose of this analysis is to describe the clinical and economic outcomes of patients diagnosed with NVP utilizing an outpatient program of nursing support and pharmacologic treatment with subcutaneous metoclopramide (SMT)...