Molecular docking is routinely used for understanding drug-receptor interaction in modern drug design. Here, we describe the docking of 2, 4-diamino-5-methyl-5-deazapteridine (DMDP) derivatives as inhibitors to human dihydrofolate reductase (DHFR). We docked 78 DMDP derivates collected from literature to DHFR and studied their specific interactions with DHFR. A new shape-based method, LigandFit...

Exercise combined with dietary factors may have significant effects on the suppression of body fat accumulation. Several trials suggest that amino acid mixtures containing alanine, arginine, and phenylalanine (ARF) exercise can significantly reduce accumulation in overweight adults high-fat diet-induced obesity mice. We therefore hypothesized combining ARF would induce beige adipocyte formation...

Potato tubers are susceptible to wounding during post-harvest processes, leading quality decline, perishability and large economic losses. In this study, the potato cultivar, ‘Longshu No.7′, was foliar-sprayed with 3% chitosan (w/v) three times pre-harvest period after flowering evaluate effect of foliar spraying on suberization processing in wounds harvested tubers. Our results demonstrated th...

The purpose of the current research is investigating the phenylalanine removal by using magnetic nanoparticles (Fe3O4) from water samples. The effect of pH, contact time and phenylalanine concentration on phenylalanine adsorption efficiency by magnetite nanoparticles are studied in a batch system. Transmission electron microscopy (TEM), X-ray Diffraction Patterns (XRD) and...

background there is evidence in support of low bone density in young patients with disorders of phenylalanine metabolism; however, little is known about muscle and fat mass in these patients, especially in those with mild hyperphenylalaninemia (mhpa). objectives we aimed to evaluate body composition of children and adolescents with early-diagnosed disorders of phenylalanine metabolism. patients...

To investigate the enzyme variations responsible for the synthesis of phenolics, 40 day-old adventitious roots of Panax ginseng were treated with 200 microM methyl jasmonate (MJ) or salicylic acid (SA) in a 5 L bioreactor suspension culture (working volume 4 L). Both treatments caused an increase in the carbonyl and hydrogen peroxide (H2O2) contents, although the levels were lower in SA treated...

Abstract Gray mold, caused by Botrytis cinerea, poses a significant threat to the strawberry industry worldwide. B. cinerea is high-risk pathogen in sense of fungicide resistance. The sensitivities isolates collected from Zhejiang Province, China, succinate dehydrogenase inhibitors (SDHIs) boscalid and Y12196 were determined based on discriminatory dose or 50% effective concentration (EC 50 ). ...

The NAD-dependent isocitrate dehydrogenase [threo-D(S)-isocitrate:NAD(+) oxidoreductase (decarboxylating); EC 1.1.1.41] from pig heart is a multisubunit enzyme with a molecular weight of approximately 340,000. Electrophoresis of the enzyme in 10% polyacrylamide gels containing sodium dodecyl sulfate reveals two discrete bands with molecular weights of 41,000 and 39,000. The two bands exhibit ap...