the one-pot, multi-component synthesis of 4,4′-(arylmethylene)bis(1h-pyrazol-5-ols) by tandem knoevenagel-michael reaction of phenylhydrazine, ethyl acetoacetate and aldehydes in the presence of silica-bonded n-propylpiperazine sulfamic acid (sbppsa) as a recyclable solid acid catalyst was reported. sbppsa showed much the same efficiency when used in consecutive reaction runs.

Introduction: Stem bark of Lannea kerstingii is used in Togo for its anti-anemic effect. The aim this study was to verify the efficacy extracts L. kerstingii’s treatment anemia and explore mechanism action. Materials Method: stem collected city Kpalimé, located at 120 km northwest Lomé. Hydromethanolic extract obtained by evaporation. Two protocols were carried out 20 twelve-week-old rats that ...

A series of fourteen patients with polycythaemia due to hypoxic lung disease has been treated with a combination of phenylhydrazine hydrochloride and pyrimethamine to reduce the haematocrit level, with doses usually of up to 100 mg/day (and rarely up to 150 mg/day) of the former and never more than 12-5 mg/day of the latter. Successful reduction of the haematocrit level was achieved in every ca...

[reaction: see text] A novel one-pot synthesis of indole systems via tandem hydroformylation/Fischer indole synthesis starting from olefins and arylhydrazines is described. This tandem procedure leads directly to 3-substituted indoles if unsubstituted phenylhydrazine is used and to 3,5- respectively 3,7-disubstituted indoles if para- or ortho-substituted arylhydrazines are used.