SCN8A encodes Nav1.6, one of the main voltage-gated sodium channel subunits in the brain, and SCN8A mutations lead to epileptic encephalopathy. Particular mutations render the mutant channel more susceptible to inhibition by phenytoin. Yet, the potentially severe side effects of phenytoin maintenance therapy, especially cognitive impairment, are undesirable in these already cognitively impaired...

The objective of the present study was to investigate the effects of the antiepileptic drugs, gabapentin and phenytoin, on sperm morphology in Wistar rats. Groups (n=5) of rats were treated with cyclophosphamide (20 mg/day), gabapentin (16, 25, 32 mg/day) and phenytoin (3.5, 5.5, 7 mg/day) for five consecutive days. 14 and 35 days after the last exposure, sperm morphology was evaluated by stand...

In clinical practice, therapeutic drug monitoring (TDM) makes it possible to measure the concentration of drugs in serum or saliva, purpose which is reduce adverse effects and optimize pharmacological therapy. The objective was determine concentrations Phenytoin saliva people with epilepsy. Cross-sectional, descriptive study dynamic recruitment 30 epilepsy (n = 30; 17 men, 56.7% 13 women, 43.3%...

This fiber optic sensor, based on a homogeneous fluorescence energy-transfer immunoassay, operates in a continuous, reversible manner to quantify the anticonvulsant drug phenytoin. B-Phycoerythrin-phenytoin and Texas Red-labeled antibody to phenytoin were sealed inside a short length of cellulose dialysis tubing, which was cemented to the distal end of an optical fiber. When the sensor was alte...

Chronic administration of phenytoin has been associated to have a number of adverse effects. Falling serum folate levels is one such most often reported adverse drug sequelae of long term phenytoin usage. Folates administered at pharmacological doses, on the other hand, have been blamed for a decrease in the serum concentration of phenytoin, severe enough to precipitate seizures. This review su...

Oral phenytoin is an extensively used medicine for the treatment of convulsive disorders. Topical phenytoin has also been used for various types of ulcers. To determine the effectiveness of 2% topical phenytoin sodium solution in treating recalcitrant pyoderma gangrenosum. Six patients with treatment-resistant pyoderma gangrenosum who attended to Dermatology Unit/Ward were taken to the study an...

57 INTRODUCTION Drug-induced gingival overgrowth is a disfiguring side effect of anticovulsants, calcineurin inhibitors, and calcium channel blocking agents. Phenytoin is an antiepileptic drug that acts on sodium channels in mammal cells. Clinically detectable gingival overgrowth occurs as the principal side-effect of phenytoin therapy in approximately half of the treated patients. Although the...

Phenytoin monotherapy in patients with epilepsy affects calcium metabolism and bone turnover markers leading to hypovitaminosis D, hypocalcemia, reduced bone mineral density and its imminent consequences. This study was planned to assess how early these changes may arise and to find out their correlation with phenytoin levels. In this prospective study, bone mineral density (BMD), 25-hydroxy vi...

We herewith describe a topical formulation of phenytoin with a clear analgesic effect in localized neuropathic pain: in post herpetic neuralgia and trigeminal neuralgia. Such topical analgesic effect for phenytoin has not yet been described in literature. We have developed various topical phenytoin formulations and identified a stable cream base in which we compounded a range of concentrations ...

We report kinetic studies on the reaction of a latex agglutination immunoassay used to quantify phenytoin in serum. In this assay, polystyrene particles with a covalently attached analog of phenytoin react with an antiphenytoin monoclonal antibody to form light-scattering aggregates, with the rate of this reaction being decreased by addition of phenytoin from sample. In the absence of free (sam...