UNLABELLED: Renal control of systemic phosphate homeostasis is critical as evident from inborn and acquired diseases causing renal phosphate wasting. At least three transport proteins are responsible for renal phosphate reabsorption: NAPI-IIa (SLC34A1), NAPI-IIc (SLC34A3) and PIT-2 (SLC20A2). These transporters are highly regulated by various cellular mechanisms and factors including acid-base ...

Organisms require elements to live and reproduce. We already know that availability of certain elements [e.g. phosphorus (P)] is highly variable spatiotemporally. In addition, there is variability in demand for various elements ontogenetically, as well as phylogenetically. Nonetheless, we know little about the underlying causes for such variation. In this study, we surveyed the literature to id...

In the sugar phosphate transporter UhpT, gain-of-function derivatives that prefer phosphoenolpyruvate (PEP) as substrate have an uncompensated lysine residue on transmembrane segment 11. We show here that these variants are also highly susceptible to substrate-protectable inhibition by covalent modification of lysine with pyridoxal 5-phosphate. The chemical requirements of this interaction prov...

Submit Manuscript | http://medcraveonline.com Abbreviations: AIA: Adjuvant-Induced Arthritis ; AST: Aspartate Amino Transferase; BSA: Bovine Serum Albumin; DON: 6-Diazo5-Oxo-L-Norleucine; DRG: Dorsal Root Ganglia; GLU: Glutamate; GLS: Glutaminase; IR: Immunoreactivity; MRNA: Messenger RNA; NSAID: Non-Steroidal Anti-Inflammatory Drug; PBS: Phosphate Buffered Saline; PBST: Phosphate Buffered Sali...

The discovery of phosphate (Pi) transporter genes has provided a basis for the molecular study of the complex pattern of Pi transport in plants. Over the past two years, a significant amount of information has been generated on the molecular regulation of phosphate transport in plants. Recent developments in plant genomics will soon allow the complete dissection of the signal transduction pathw...

Mycorrhizal associations are known to improve the hydro-mineral nutrition of their host plants. However, the importance of mycorrhizal symbiosis for plant potassium nutrition has so far been poorly studied. We therefore investigated the impact of the ectomycorrhizal fungus Hebeloma cylindrosporum on the potassium nutrition of Pinus pinaster and examined the involvement of the fungal potassium t...

PHOSPHATE TRANSPORTER TRAFFIC FACILITATOR1 (PHF1) is known to regulate the plasma membrane localization of PHT1;1, a high-affinity inorganic phosphate (Pi) transporter in Arabidopsis (Arabidopsis thaliana). OsPHF1, a rice (Oryza sativa) gene homologous to AtPHF1, was isolated and found to regulate the localization of both low- and high-affinity Pi transporters to the plasma membrane. Three OsPH...

Acidocalcisomes are acidic organelles present in a diverse range of organisms from bacteria to human cells. In this study acidocalcisomes were purified from the model organism Trypanosoma brucei, and their protein composition was determined by mass spectrometry. The results, along with those that we previously reported, show that acidocalcisomes are rich in pumps and transporters, involved in p...