Antimycobacterially active salicylanilide diethyl phosphates were evaluated to identify their potential drug target(s) for the inhibition of several mycobacterial enzymes, including isocitrate lyase, L-alanine dehydrogenase (MtAlaDH), lysine ε-aminotransferase, chorismate mutase, and pantothenate synthetase. The enzymes are related to the nongrowing state of Mycobacterium tuberculosis. Salicyla...

This study examined the ability of the excitatory amino acid glutamate and its analogs to stimulate phosphatidylinositol metabolism in isolated cochlear nucleus tissue from young chicks. In the presence of lithium chloride, glutamate and (+/-)-1-aminocyclopentyl-trans-1,3-dicarboxylate (ACPD) stimulated the formation of inositol phosphates to levels significantly above unstimulated control leve...

Hollow magnetic Fe3O4@NH2-MIL-101(Fe) derived from metal-organic frameworks are fabricated through a general facile strategy. The synthetic parameters are regulated to control the shape of the as-prepared samples. The concentration of phosphates decreased sharply from the initial 0.60 to 0.045 mg.L(-1) with the exposure time in 50 minutes. The correlation between the most significant parameters...

In this paper we introduce the SpeakCorrect system which is a Computer Aided Pronunciation Training (CAPT) system for native Arabic students of English. The system is designed with optimized performance for the target users group. It is L1 dependent system and only the frequent pronunciation errors of native Arabic speakers are examined. Several adaptation techniques such as Speaker Adaptive Tr...

Solubil ity is one of the most important properties of calcium phosphate salts. It is the solubil ity that determines the direction of many reactions that involve calcium phosphates such as dissolution, precipitation, hydrolysis, and phase transformation. Calcium phosphate solubil ity also plays a maior role in biological processes that involve formation and resorption ol' hard tissues as well ...

infections Widad Al-Nakib, FRCPath, FIDSA; Sahar Essa, BSc, MSc, PhD; Haya Altawalah, BSc, MBBS, FRCPath; Abdullah Owayed; Mousa Khadadah; Nasser Behbehani; Microbiology Department Kuwait University, Faculty of Medicine, Kuwait; Virology Unit, Ministry of Health, Mubarak Hospital, Kuwait; Paediatrics, Kuwait University, Faculty of Medicine, Kuwait; Medicine, Kuwait University, Faculty of Medici...

Inositol (me8oinositol or myoinositol) occurs very widely in plants, animals and micro-organisms (Fleury & Balatre, 1947; Courtois, 1951; Hawthorne & Chargaff, 1954; Mann, 1954a). It occurs in the free state as well as in the form of inositol phosphatides, while in plants it is often present as the hexaphosphate, phytic acid. Treatment of liver and nervous tissue by the standard procedure of Sc...

The xylene ring of riboflavin originates by dismutation of the precursor, 6,7-dimethyl-8-ribityllumazine. The formation of the latter compound requires a 4-carbon unit as the precursor of carbon atoms 6 alpha, 6, 7, and 7 alpha of the pyrazine ring. The formation of riboflavin from GTP and ribose phosphate by cell extract from Candida guilliermondii has been observed by Logvinenko et al. (Logvi...