Inositol phosphates (InsPs) are intricately tied to lipid signaling, as at least one portion of the inositol phosphate signaling pool is derived from hydrolysis of the lipid precursor, phosphatidyl inositol (4,5) bisphosphate. The focus of this review is on the inositol pyrophosphates, which are a novel group of InsP signaling molecules containing diphosphate or triphosphate chains (i.e., PPx) ...

In developing a new quantitative AP-MS method for exploring interactomes in the chicken B-cell line DT40, we also surveyed the most abundant proteins in this organism and explored the likely contaminants that bind to a variety of affinity resins that would later be confirmed quantitatively [1]. We present the 'Top 150 abundant DT40 proteins list', the DT40 beadomes as well as protein interactio...

There are several signal mechanisms involved in platelet activation, including specific receptors, G proteins, phosphatidyl inositol metabolism, synthesis of thromboxane A2 (TXA2) and other eicosanoids, changes in cytosolic calcium, and protein phosphorylation, in serine/threonine and tyrosine residues[2]. These signal mechanisms result in a conformational change in the GP IIb IIIa receptor, pl...

This paper describes experiments on Cl transport into the roots, stem and leaves of bean plants, the roots of which have been exposed to lipids in the root solution. Monoand digalactose diglyceride strongly increased Cl transport into all plant parts, probably by transport of the glycolipids further into the plant. Phosphatidyl choline increased Cl absorption by the roots, but transport into th...

Article history: Received on: 25/05/2016 Revised on: 17/06/2016 Accepted on: 10/07/2016 Available online: 30/08/2016 Phospholipid is very essential in the balanced diet. The vegetarian people in the coastal area are habitant of using edible oil seeds as daily food grains. Salinity of water during cultivation decreases the accumulation of oil content (12-15%) in seeds. Present experiment was foc...

BACKGROUND Recurrent pregnancy loss (RPL) has been associated with antiphospholipid antibodies (APA) including anticardiolipin and lupus anticoagulant. Therapy using heparin and aspirin has been shown to significantly improve the live birth rate. We evaluated whether other APA should be considered as a basis for treatment in women with RPL. We also assessed the efficacy of heparin and aspirin t...

The glycome, i.e. the cellular repertoire of glycan structures, contributes to important functions such as adhesion and intercellular communication. Enzymes regulating cellular glycosylation processes are related to the pathogenesis of cancer including multiple myeloma. Here we analyze the transcriptional differences in the glycome of normal (n = 10) and two cohorts of 332 and 345 malignant pla...

Abstract The cellular DNA damage response (DDR) is a key factor in tumor suppression and responses to genotoxic chemo- radiotherapy. Master DDR regulators include three phosphatidyl inositol 3′ kinase–related kinases (PIKK) called ATM, ATR, the catalytic subunit of DNA-dependent protein kinase, DNA-PKcs. Among their many functions, PIKKs regulate repair double-strand breaks (DSB) by homologous ...