Integrin-mediated adhesion regulates cellular responses to changes in the mechanical and biochemical properties of extracellular matrix. Cell–matrix caveolar endocytosis, dependent on caveolin 1 (Cav1) Tyr14 phosphorylation (pY14Cav1), control anchorage-dependent signaling. We find that cell–matrix pY14Cav1 levels mouse fibroblasts. Biochemical fractionation reveals endogenous be present caveol...

Fetuin-A is a phosphorylated glycoprotein produced by liver.It by binding to calcium ion inhibits ectopic calcium deposition and protects vascular calcification. Fetuin-A acts as a multifactorial protein and its role has been documented from brain development to bone remodeling and immune function, regulation of insulin activity, hepatocyte growth factor activity and inhibition lymphocyte blast...

The aim of the present study was todeterminecharacteristics of Rheb gene and protein in Raini Cashmere goat. Comparative analyses of the nucleotide sequences were performed. Open reading frames (ORFs), theoretical molecular weights of deduced polypeptides, the protein isoelectric point, protein characteristics and three-dimensional structures was predicted using online standard softwares. The f...

Background: Mutation of p53 is a frequent event, and mutant exhibits low levels acetylation phosphorylation. This study aimed to investigate the effect histone deacetylase (HDAC) inhibitor, 4-hexylresorcinol (4HR), on phosphorylation carcinoma cells its therapeutic effects in xenograft model. Methods: To determine 4HR p53, western blot analysis was performed using YD-9 YD-15 cells. siRNA used e...