The physicochemical parameters of groundwater at Auchi and South-Ibie were investigated to determine underground water quality in this environment. Water sampled locations categorized as Iyekhei (Iyekhei), Poly (Auchi PW), Hostel PH), Double Delight (DDH); are Levis Gas Plant (LGP), Pastoral Centre (PC), Global Castle Sawmill Road (GCHS), Arsenal and, Lagos Street (AHLS). A total number 80 samp...

An iterative analogue library synthesis strategy rapidly developed comprehensive SAR for the mGluR5 ago-potentiator ADX-47273. This effort identified key substituents in the 3-position of oxadiazole that engendered either mGluR5 ago-potentiation or pure mGluR5 positive allosteric modulation. The mGluR5 positive allosteric modulators identified possessed the largest fold shifts (up to 27.9-fold)...

Small molecule chemotherapeutics often have undesired physiochemical and pharmacological properties, such as low solubility, severe side effect and narrow therapeutic index. To address these challenges, polymeric nanomedicine drug delivery technology has been routinely employed, in particular with the use of biodegradable and biocompatible polyesters, such as poly(lactide) (PLA) and poly(lactid...