Sarcoids are the most prevalent equine skin tumours and remain a therapeutic challenge due to their differing clinical morphology, local aggressive behaviour, and high recurrence following surgical treatment. In vitro, sarcoid derived fibroblasts are invasive and express matrix metalloproteinase (MMP) -1, -2 and -9. It was hypothesised that the MMPs produced by neoplastic cells play a role in b...

The title compound, [Fe(C64H64N8O4)Cl], is a five-coordinate square-pyramidal porphyrin complex with a chloride ion in the axial position, being coordinated from the protected side of the porphyrin; the Fe(III) atom is displaced by 0.474 (5) Å from the 24-atom mean plane of the porphyrin core towards the chloride. The porphyrin moiety is a 'picket-fence' 5,10,15,20-tetra-kis-[2-(2,2-di-methyl-p...

Three-dimensional images of the undercoat structure on the cytoplasmic surface of the upper cell membrane of normal rat kidney fibroblast (NRK) cells and fetal rat skin keratinocytes were reconstructed by electron tomography, with 0.85-nm-thick consecutive sections made approximately 100 nm from the cytoplasmic surface using rapidly frozen, deeply etched, platinum-replicated plasma membranes. T...

A case of benign cystic mesothelioma in a 53-year-old woman is presented. The patient had abdominal pain and a palpable mass for 4 days. This mass was noticed incidentally by an obstetrician. A computed tomographic scan of the abdomen and pelvic sonography showed a cystic mass, 6 x 4 cm, in the right lower quadrant close to the cecum and suggested cystadenocarcinoma of the ovary. Operation show...

The Sounding of the Atmosphere using Broadband Emission Radiometry (SABER) instrument, a 10-channel infrared (1.27 16.9 μm) radiometer, was launched on the TIMED (Thermosphere, Ionosphere, Mesosphere Energetics and Dynamics) satellite in December 2001 from Vandenburg Air Force Base. SABER is being used to measure earthlimb emissions and to characterize infrared radiation, allowing calculation o...

One well-known way to constrain the hydrogen neutral fraction, x̄HI, of the high-redshift intergalactic medium (IGM) is through the shape of the red damping wing of the Lyα absorption line. We examine this method’s effectiveness in light of recent models showing that the IGM neutral fraction is highly inhomogeneous on large scales during reionization. Using both analytic models and “semi-numeric...

We report the first measurement of the vibrational Stark effect in a protein, providing quantitative information on the sensitivity of a vibrational transition to an applied electric field. This can be used to interpret changes in the vibrational frequency that are often observed when amino acids are changed or when a protein undergoes a structural change in terms of the change in the internal ...

We consider the behavior of open quantum systems through the dependence of the coupling to one decay channel by introducing the coupling parameter alpha, which is proportional to the average degree of overlapping. Under critical conditions, a reorganization of the spectrum takes place that creates a bifurcation of the time scales with respect to the lifetimes of the resonance states. We derive ...