OBJECTIVE To investigate prognostic indicators in an aggressive Crooke's cell adenoma of the pituitary. METHODS The surgically removed tumor was studied by histology, immunohistochemistry and transmission electron microscopy. RESULTS An aggressive invasive sellar tumor removed by repeated surgeries from a 43-year-old woman with pituitary related Cushing's disease was classified as a Crooke'...

Endocrinologically active pituitary adenomas are treated either with surgery, radiotherapy or various drugs, including dopamine agonists, long-acting somatostatin analogs, growth hormone receptor antagonists, or corticosteroid secretion inhibitors. Fully 35% to 55% of pituitary adenomas invade adjacent structures. This figure is lower in gonadotroph adenomas, less than 5% compared to other aden...

Previous studies have shown that CCNB1 affects the invasiveness of pituitary adenomas, and it is great significance to find upstream mechanism regulating CCNB1.In this study, we explored a significantly overexpressed circRNA in invasive adenomas. Based on bioinformatics analysis experiments, determined circNFIX (has-circ_0005660) cell invasion, migration proliferation adenomas by sponging miR-3...

Gangliocytoma of the pituitary gland is a rare lesion that often occurs in combination with pituitary adenomas and the exact origin is the subject of discussion. We report a rare case of an intrasellar mass of combined gangliocytoma/ pituitary adenoma coexistent with Rathke's cleft cyst. A 50-year-old female was admitted to our hospital with headache, mild acromegaly, and bitemporal hemianopsia...

A tumoral mass at the clivus is uncommon and its differential diagnosis presents a challenge, since many different tumours may result in a similar radiological image. A chordoma is the most common of these tumours and represents 40% of all cases. Less common, in decreasing order of frequency, are meningiomas, astrocytoma, germinal cell tumours, lymphoma, metastases and, finally, pituitary adeno...

Diseases responsive to glucocorticoids, like sarcoidosis, are rarely masked by Cushing's syndrome. An ACTH secreting pituitary adenoma is a possible cause of Cushing's syndrome and its resection can make a subclinical sarcoidosis clear. Only few cases of sarcoidosis following the treatment of hypercortisolism are reported in literature. We report a case of sarcoidosis after the resection of an ...

Multiple Endocrine Neoplasia type 2A (MEN-2a) is a rare disease associated with tumors of endocrine organs. Presentation most commonly is with medullary thyroid cancer and infrequently with other complaints. Pituitary adenoma has been seen coincidentally with this disease very rarely. Presented is a case of coincident MEN-2a with a symptomatic pituitary adenoma and an asymptomatic pheochromocyt...

BACKGROUND AND PURPOSE We report the first case of pituitary apoplexy caused by the rupture of an intracavernous carotid artery aneurysm embedded in a pituitary adenoma. CASE DESCRIPTION A 46-year-old man presented with clinical and CT findings typical of pituitary apoplexy. MRI showed an unusual flow-void protrusion into the intratumoral hematoma, which, however, was not diagnosed as a ruptu...

OBJECTIVE The surgical approach for recurrent pituitary adenoma after trans-sphenoidal approach (TSA) is challenging. We report the outcomes of the endoscopic TSA for recurrent pituitary adenoma after microscopic TSA. METHODS From February 2010 to February 2013, endoscopic TSA was performed for removal of 30 recurrent pituitary adenomas after microscopic TSA. Twenty-seven (90%) patients had a...

The concomitant presence of three histopathologically different entities in the pituitary gland is a rare occurrence. Most publications identify at least two distinct pathologies, mainly, a pituitary adenoma coexisting with a second intrasellar lesion. We present a case of a 71-year-old female referred for evaluation and treatment of acromegaly. Questioning revealed she was experiencing facial ...