A IM : to evaluate efficacy and safety of ustekinumab in Russian patients with ulcerative colitis UNIFI study. PATIENTS AND METHODS: the program (CNTO1275UCO3001) consisted two randomized placebo-controlled trials: an 8-week induction study a 44-week maintenance long-term period. This analysis included from 14 centers. RESULTS enrolled 74 Russia, 89.2% (n = 66) were bionaive. The paper presents...

background and aims: laryngospasm and vomiting occurring after tracheal extubation in children is potentially dangerous. the aim of this study was to investigate the effects of preoperative 0.5 mg/kg i.v. dexamethasone on the incidence of postextubation laryngospasm, and vomiting in children after tonsillectomy.material and methods : this study was performed at the ilam imam khomeini hospital, ...

purpose: to evaluate the effect of oral prednisolone on visual outcome and complications of scleral buckling (sb) in patients with rhegmatogenous retinal detachment (rrd). methods: in a randomized double-blind placebo-controlled trial, patients with acute rrd who underwent sb were randomly divided into two groups. oral prednisolone was administered for the treatment group and placebo for the co...

Background and aim: Paederus dermatitis is an acute self-healing blistering disease caused by an insect from the genus Paederus species. Although it is a self-limited disease, it can cause disablement and suffering. The objective of this study was to investigate the efficacy of fluocinolone cream, triclocarban(TCC) soap and betamethasone lotion in comparison with placebo in the treatment ...

Abstract Placebo use in clinical trials, whenever a proven effective treatment exists, is one of the most debated topics contemporary research ethics. This article addresses ethical framework for placebo trials assessing vaccine efficacy pregnant women. Vaccine trial participants are healthy at outset and some must be infected during study to demonstrate product’s efficacy, meaning that placebo...

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medical therapies have been widely used for premenstrual syndrome (pms), but in all of them side effects are predominant. herbal remedies rarely have side effects and people have more tendencies toward them than chemical therapies. in this study the therapeutic effect of vitex agnus castus on women who had the pms, in comparison with placebo, were investigated. in this randomized, placebo-contr...

conclusions the present study showed that g-csf is not superior to placebo in production of protective antibody titers after hbv vaccination but could result in a more rapid antibody response, compared to the placebo. results there was no statistically significant difference between anti-hbv antibody titers in patients receiving double dose hbv vaccination plus g-csf and patients receiving doub...

Background and objectives: Urinary incontinence is a public complaint that causes discomfort, embarrassment and costs. Also, there are some limitations and insufficiencies of drug therapy and surgical complications. This study has compared the effect ofSaussurea costus (qost) oil as an Iranian traditional medicine product and other contemporary medicine treatment metho...

Starting biologic treatment early in the course of inflammatory bowel disease (IBD) may associate with higher efficacy, especially Crohn’s (CD). A systematic review and individual-patient-data meta-analysis all placebo-controlled trials biologics approved for IBD at study inception (Oct 2015), using Vivli data-sharing platform. The primary outcome was proportional biologic/placebo effect on ind...