in recent years, great efforts have been devoted to the design of drug delivery systems. many polymeric excipients have been studied in order to make drug release fit the desired profiles. the aim of this work was to design a theophylline oral suspension, as sustained release pharmaceutical preparation in order to decrease the plasma level fluctuations and adverse effects of theophylline. micro...

Plasma spray-physical vapor deposition (PS-PVD) is an emerging technology for the of uniform and large area coatings. As characteristics plasma jet are difficult to measure in whole chamber, computational fluid dynamics (CFD) simulations could predict temperature, velocity pressure fields. However, as PS-PVD generally operated at pressures below 500 Pa, a question rises about validity CFD predi...

Titanium is widely used for medical purposes. It related to bone repair because of its favorable mechanical properties and biocompatible ability osseointegrate in host tissue. A good lasting connection the implant with tissue possible when there are sufficient conditions grow into pores material, therefore use a porous titanium coating may be helpful solving this problem. In paper, shrouded pla...

Highly crystalline feedstock hydroxyapatite (HA) particles with irregular shapes were spheroidized by plasma spraying them onto the surface of ice blocks or into water. The spherical Ca-P particles thus produced contained various amounts of the amorphous phase which were controlled by the stand-off distance between the spray nozzle and the surface of ice blocks or waiter. The smooth surface mor...

AIMS The study was designed to evaluate the relative bioavailability of diclofenac in plasma, subcutaneous adipose and skeletal muscle tissue after repeated topical administration using MIKA Diclofenac Spray Gel (4%), a novel formulation, and after oral dosing using VOLTAREN 50 mg enteric coated tablets. METHODS Diclofenac (48 mg) was administered topically three times daily for 3 days onto a...

Low-pressure plasma spraying (LPPS) is a promising method of applying coatings to surfaces for thermal, chemical, and mechanical protection. The deposition of coatings with superior properties requires an improved understanding of this complex spray process, including the detailed understanding of the time–temperature and chemical history to which an injected particle is exposed during its trav...