Persistent thrombocytopenia may be the consequence of chronic infections with hepatitis C virus (HCV), human immunodeficiency virus (HIV), and Helicobacter pylori, and should be considered in the differential diagnosis of primary immune thrombocytopenia (ITP). Studies have shown that on diagnosis of infections, treatment of the primary disease often results in substantial improvement or complet...

BACKGROUND It has long been postulated that Protein Kinase C (PKC) is an important regulator of megakaryopoiesis. Recent contributions to the literature have outlined the functions of several individual PKC isoforms with regard to megakaryocyte differentiation and platelet production. However, the exact role of PKCε remains elusive. OBJECTIVE To delineate the role of PKCε in megakaryopoiesis....

After an almost 40-year search for a primary regulatory of platelet production, thrombopoietin has recently been purified and cloned. Thrombopoietin regulates all stages in the production of platelets by promoting both the proliferation of megakaryocyte progenitors and their maturation into platelet-producing megakaryocytes. In preclinical studies in normal mice and non-human primates, administ...

blood transfusion centers are under considerable pressure to produce platelet concentrates with a shelf life limit of 3 to 5 days. many approaches have been investigated experimentally to produce new hemostatically active platelet products that are capable of long term storage. in this article infusible platelet membrane will be explained as a platelet substitute versus conventional liquid-stor...

BACKGROUND Platelet deficiency, impaired platelet function, or both increase the risk of bleeding complications. We assessed platelet count and function during and after paediatric cardiac surgery. Secondary aims included the effect of modified ultrafiltration, identification of factors associated with platelet dysfunction, and to assess associations between platelet function and transfusion re...

Background. In team sports, according to perform variety of motor skills, development of special bio-motor abilities and imposed proper exercise stress, hematologic adaptations following exercise will be different. Objectives. Therefore, the aim of this study was the effects of six weeks combined training program on hematological parameters in elite basketball players. Methods. Fifteen athl...

A CUTE DEPLETION OF CIRCULATING PLATELETS IN ANIMALS is followed by a period of reactive thrombocytosis before the platelet counts finally return to normal. This overcompensation suggests that the rate of production of platelets is increased in response to thrombocytopenia, and this notion has been substantiated by the demonstration of changes in megakaryocyte size,’ a maturation rate4’5 and nu...