UNLABELLED Herein, for the first time, we combined poly-l-lactic acid (PLLA) with a strontium borosilicate bioactive glass (BBG-Sr) using electrospinning to fabricate a composite bioactive PLLA membrane loaded with 10% (w/w) of BBG-Sr glass particles (PLLA-BBG-Sr). The composites were characterised by scanning electron microscopy (SEM) and microcomputer tomography (μ-CT), and the results showed...

Atmospheric pressure non equilibrium plasma treatments have been implemented to produce solvent-free Poly-L-lactic acid (PLLA) scaffolds, to improve biocompatibility of PLLA mats and to increase electrolyte uptake of Poly(vinylidene fluoride) (PVDF) separators for lithium batteries. It has been observed that plasma treatments are a suitable way to improve polymeric solution electrospinnability,...

In this work, nanocomposite membranes based on graphene and polylactide were evaluated for mechanical properties biocompatibility. Single-layer (SLG), nanosheets (GNS), poly L-lactic acid (PLLA) prepared through layer-by-layer deposition homogeneous mixing. The results revealed that PLLA/SLG nanocomposites PLLA/GNS could show enhanced addition of a tiny amount SLG significantly improved Young’s...

Poly-L-lactic acid (PLLA) electrospun nanofiber scaffold is one of the most commonly used synthetic polymer scaffolds for bone tissue engineering application. However, PLLA is hydrophobic in nature, hence does not maintain proper cell adhesion and tissue formation, moreover, it cannot provide the osteo-inductive environment due to inappropriate surface characteristic and the lack of surface mot...

Poly(L-lactic acid) (PLLA) was immersed in a simulated body fluid (SBF) solution at 37.58C for distinct times. The variation of the surface mechanical properties of PLLA samples with immersion time was followed by microhardness. These measurements showed that PLLA microhardness decreased significantly ( 60%) after only 30 days of immersion. The results were explained in terms of hydrolytic degr...

BACKGROUND Two methoxyl poly(ethylene glycol)-poly(L-histidine)-poly(L-lactide) (mPEG-PH-PLLA) triblock copolymers with different poly(L-histidine) chain lengths were synthesized. The morphology and biocompatibility of these self-assembled nanoparticles was investigated. METHODS Doxorubicin, an antitumor drug, was trapped in the nanoparticles to explore their drug-release behavior. The drug-l...

Nanoindentation of cellulose diacetate-graft-poly(lactide)s (CDA-g-PLLAs) synthesized by ring opening graft copolymerization of L-lactide in bulk onto the residual hydroxyl positions on CDA were conducted to investigate the effect of the molecular composition and thermal aging on mechanical properties and creep behavior. Continuous stiffness measurement (CSM) technique was used to obtained hard...

Background: Polyesters have been attractive for development of drug delivery applications because of their biocompatible, biodegradable and non-toxic properties. The objective of work is a comparative study on the release characteristics of two drugs loaded poly (L-lactide) (PLLA) film. Progesterone (Pro) and lidocaine hydrochloride (LidH) were chosen as the hydrophobic and hydrophilic model dr...

In bone engineering, the adhesion, proliferation and differentiation of mesenchymal stromal cells rely on signaling from chemico-physical structure of the substrate, therefore prompting the design of mimetic "extracellular matrix"-like scaffolds. In this study, three-dimensional porous poly-L-lactic acid (PLLA)-based scaffolds have been mixed with different components, including single walled c...