Zebrafish has been gaining increasing amount of interest in behavioral neuroscience as this species may represent a good compromise between system complexity and practical simplicity. Particularly successful have been those studies that utilized zebrafish as a screening tool. Given the complexity of the mechanisms of learning, for example, forward genetic screens with zebrafish could potentiall...

One of the factors responsible for high prevalence and attendant socio-economic burden anxiety disorders is paucity slow pace discovery new anxiolytic drugs to complement or replace existing ones due attrition rates poor translation preclinical drug efforts clinical usage. This scenario viewed arise from certain including inherent sensitivity idiosyncrasies most used individual classical tests/...

Some studies suggested that glucocorticoid receptors activities can modulate fear and anxiety. According to that, the purpose of this research is to assess the modulatory effect of glucocorticoid receptors on the anxiety assessed in plus maze. In this research mice with medium weight of 20-25 g were used. The male and female animals separately sorted in two groups as control and experiment rand...

Post-training intracerebroventricular administration of procaine (20 micrograms/microliter) and dimethocaine (10 or 20 micrograms/microliter), local anesthetics of the ester class, prolonged the latency (s) in the retention test of male and female 3-month-old Swiss albino mice (25-35 g body weight; N = 140) in the elevated plus-maze (mean +/- SEM for 10 male mice: control = 41.2 +/- 8.1; procai...

The present study addressed the role of environmental light intensity on the exploratory behavior of rats in the elevated plus-maze, with the specific goal of determining the light intensity threshold for triggering the aversion to the open arms. Male Wistar-derived rats were tested in the elevated plus-maze under different illumination levels: 0, 1, 3, 10, 30, 100 and 300 lx. Exploratory behav...

Argyreia speciosa (Convolvulaceae) is regarded as a ‘Rasayan’ drug in the Ayurveda system of medicine to cure diseases of the nervous system. This work researched the action of the hydroalcoholic extract of A. speciosa root (ASE) on experimentally-induced anxiety, depression and convulsion in rodents. ASE (100, 200, 500 mg/kg, p.o.) was tested for the elevated plus maze, open field, forced swim...