BACKGROUND Oxidative stress contributes to both intraocular pressure regulation and glaucomatous neuropathy. The systemic redox status (solitary determination) was examined in primary open-angle glaucoma (POAG) patients with cataract and nonglaucomatous cataract patients. Cataract-matched group comparisons appear more precise in the context of oxidative stress evaluation. The aim of this study ...

BACKGROUND Loss of vision in glaucoma is due to apoptotic retinal ganglion cell loss. While p53 modulates apoptosis, gene association studies between p53 variants and glaucoma have been inconsistent. In this study we evaluate the association between a p53 variant functionally known to influence apoptosis (codon 72 Pro/Arg) and the subset of primary open angle glaucoma (POAG) patients with early...

OBJECTIVE The evaluation of central corneal thickness (CCT) in subjects with pesudoexfoliation glaucoma (PEXG), primary open-angle glaucoma (POAG), and in normotensive individuals with or without pseudoexfoliation syndrome (PXS). STUDY DESIGN/PATIENTS AND METHODS CCT was evaluated with ultrasound pachymetry in a total of 179 individuals: 32 had bilateral PEXG, 55 had bilateral POAG, 35 had PX...

ABSTRACTOBJECTIVE: Investigation of blood lipid profile in primary open-angle glaucoma (POAG).MATERIAL AND METHODS: In this study, there were 100 participants, whom 50 patients with POAG and non-POAG consulted the ophthalmology clinic. Levels lipids including total cholesterol, low-density lipoprotein (LDL), high-density (HDL), triglyceride (TG) investigated. Data compared t-test, Mann Whitney ...

Purpose : to summarize the experience of development and application artificial neural networks (ANW) in early diagnosis primary open-angle glaucoma (POAG). Material methods . A total 690 patients (918 eyes) were tested. The training clinical group consisted 459 examples (459 eyes), which 369 eyes had an initial stage POAG 90 no glaucoma. testing was represented by 131 (131 110 belonged with 21...

Abstract Purpose To compare quantitative visual tests, such as acuity, contrast sensitivity, and color vision tests in patients with primary open-angle glaucoma (POAG) according to three different light systems color-rendering index (CRI). Methods This was a cross-sectional study of 36 eyes POAG. Three consisting 3-band fluorescent lamp (CRI 80), white LED 75), quantum dot > 95) were used. A...

INTRODUCTION Primary open-angle glaucoma (POAG) is a leading cause of visual impairment worldwide and a complex genetic disorder that affects mostly adults. Mutations in the MYOCILIN (MYOC) and OPTINEURIN genes account for rare forms with a Mendelian inheritance and for <5% of all POAG cases. The CYP1B1 gene, a member of the cytochrome P450 gene family, is a major cause of primary congenital gl...

Recently an association was observed between alleles in genes of the unfolded protein response pathway and primary open angle glaucoma (POAG). The goal of the current study is to investigate the role of these two genes, protein disulphide isomerase A member 5 (PDIA5) and baculoviral IAP repeat containing 6 (BIRC6), in different forms of glaucoma. 278 patients with POAG, 132 patients with primar...

AIMS We assessed homocysteine (Hcy) levels in tear fluid and plasma of patients with primary open-angle glaucoma (POAG). We determined the association between Hcy levels, dry eye syndrome and B vitamin status. METHODS This prospective case-control study included 36 patients with POAG and 36 controls. Hcy concentrations were measured by high-performance liquid chromatography. RESULTS Patient...

PURPOSE To evaluate whether baseline visual field data and asymmetries between eyes predict the onset of primary open-angle glaucoma (POAG) in Ocular Hypertension Treatment Study (OHTS) participants. METHODS A new index, mean prognosis (MP), was designed for optimal combination of visual field thresholds, to discriminate between eyes that developed POAG from eyes that did not. Baseline intrao...