poloxamer 188

alireza homayouni department of pharmaceutics, school of pharmacy, mashhad university of medical sciences, mashhad, iran fatemeh sadeghi 1 department of pharmaceutics, school of pharmacy, mashhad university of medical sciences, mashhad, iran 2 targeted drug delivery research center, school of pharmacy, mashhad university of medical sciences, mashhad, iran ali nokhodchi chemistry and drug delivery group, medway school of pharmacy, university of kent, me4 4tb, kent, united kingdom jaleh varshosaz department of pharmaceutics, faculty of pharmacy and novel drug delivery system research center, isfahan university of medical sciences, isfahan, iran hadi afrasiabi garekani department of pharmaceutics, school of pharmacy, mashhad university of medical sciences, mashhad, iran,pharmaceutical research center, school of pharmacy, mashhad university of medical sciences, mashhad, iran

objective(s):solid dispersion formulation is the most promising strategy to improve oral bioavailability of poorly water soluble drugs. the aim of this study was to compare the effect of polyvinylpyrrolidone k30 (pvp) and poloxamer-188 (plx) as carrier in solid dispersion formulations of celecoxib (clx). materials and methods: solid dispersions of clx:pvp or clx:plx were prepared at different r...

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