Clozapine, the second generation antipsychotic drug, is one of prominent compounds used for treatment schizophrenia. Unfortunately, use this drug still limited due to serious side effects connected its unspecific and non-selective action. Nevertheless, clozapine remains first-choice situation drug-resistance Development new strategy delivery into well-defined parts brain has been a great challe...

Over the past several decades, formulation of novel nanofiber-based drug-delivery systems has been a frequent focus scientists around world. Aiming to introduce nanofibrous transdermal system treat pain, nanofiber mats buprenorphine-loaded poly (vinyl pyrrolidone) (Bup/PVP) and poly(vinyl alcohol)/poly(vinyl (Bup/PVP/PVA) were successfully fabricated by electrospinning process for drug delivery...

BACKGROUND Reports from drug utilization reviews are important tools employed in the assessment of healthcare practices. The objective of this study was to evaluate drug utilization patterns among elderly hospitalized patients on poly-pharmacy regimens in Pakistan. METHODS A descriptive, non-experimental, cross-sectional study was carried out from December 2015 to March 2016 in six tertiary-c...

Block copolymers are able to reverse multidrug resistance (MDR) of tumor cells by a yet unknown mechanism. The drug efflux system's direct and indirect inhibition mediated by polymer P-glycoprotein (Pgp) interactions or adenosine triphosphate (ATP) depletion, respectively, may be involved in MDR reversal as well as damage to the membrane barrier caused by polymer insertion into the membrane. To...

The use of self-assembled nanoparticles for drug delivery has received significant attention in recent years. However, the dynamic nature polymeric systems means there is a need to develop greater understanding inherent stability these systems. In particular, if materials remain as discrete nanoparticles, or exchange material between particles critical. Herein, we labelled pH-responsive with fl...

A variety of ocular drug delivery systems, including a controlled release of the drug, drug targeting, and penetration enhancement of the drug, have been investigated. Biodegradable polymers have been widely used as the drug carrier for controlled-release systems. Biodegradable polymers release the drug as they themselves degrade and are finally absorbed within the body. Several ocular drug del...

Abstract This study aimed to identify the typologies of drug users and examine how they differed in drug-driving tendencies. A sample (N = 52) from Queensland, Australia, completed a telephone interview. Thematic analyses identified three unique user types: (a) sporadic recreational users, who used variety drugs drove depending on situational variables; (b) frequent favoured cannabis methamphet...