Polymorphonuclear neutrophils (PMN) are able to destroy invasive mircoorganisms by a wide variety of functions. Whereas insulin does not stimulate hexose transport in PMN, previous reports have clearly shown that this hormone regulates glucose metabolism inside this cell, raising the question of insulin action on PMN functions in humans. It is interesting that in vitro studies established a str...

Two metallo-proteinases of human neutrophil leucocytes, collagenase and gelatinase, were studied. Collagenase specifically cleaved native collagen into the TCA and TCB fragments, whereas gelatinase degraded denatured collagen, i.e. gelatin, and the TCA fragments produced by collagenase. On subcellular fractionation by zonal sedimentation, collagenase was found to be localized in the specific gr...

Introduction.?? Eosinophilia ' is very much in fashion just now in medical literature. Terms such as ' eosinophilia of lungs ' tropical eosinophilia ' and ' idiopathic eosinophilia' do certainly connote certain syndromes the existence of which cannot be denied. However, experience with certain peculiarly staining leucocytes met with under varying conditions of health may prove interesting in th...

Rush, H.G., 1989. Resistance of some capsular serotype D strains of Pasteurella multoczda to rabbit polymorphonuclear neutrophil phagocytosis. Vet Mzcrobml, 20' 79-87. The mechamsm of resistance of Capsular Type D strains of Pasteurella multoctda to killing by rabbit polymorphonuclear neutrophlls (PMN) was studmd using an in vitro assay that differentmtes intrafrom extracellular bacteria. Two C...

The present study was designed to examine the effect of Pseudomonas aeruginosa alkaline protease and elastase on human polymorphonuclear leukocyte chemiluminescence. Both a luminol-enhanced and a nonenhanced chemiluminescence system using opsonized zymosan were utilized. It was found that alkaline protease and elastase at concentrations of 25 micrograms/ml strongly inhibited luminol-enhanced my...

Recent studies identified basic biological principles that are shared by the immune and the nervous system. One of these analogies applies to the orchestration of cellular migration where guidance proteins that serve as a stop signal for axonal migration can also serve as a stop signal for the migration of immune-competent cells. The control of leukocyte migration is of key interest during cond...

......................................... Received: 05-12-11 Accepted: 15-05-12 Abstract Gastritis is an inflammation of the lining of the gastric mucosa which occurs in response to an injury. It can be acute, chronic or mixed, and it can be associated with intestinal metaplasia and atrophy. There are multiple etiologic factors including irritation, chemical, immunological, genetic and infectio...

Polymorphonuclear neutrophils (PMN) are the most abundant leucocytes in circulation humans. They represent a heterogeneous population exerting diverse functions through several activities. Usually described as typical pro-inflammatory cells, immunomodulatory properties of PMNs have been reported. Among others, once activated and depending on stimulus, expel neutrophil extracellular traps (NET) ...

The pathophysiology of vaginal conditions is still ill-defined at a molecular level. Because the proteome of the human cervical-vaginal fluid (CVF) has not been reported to date, we undertook the identification of proteins present in the cell-free fraction of these fluids. Proteins were separated bidimensionally (2-D) by isoelectrofocusing (pH 3-11) followed by SDS-polyacrylamide electrophoresi...

A C5a-receptor antagonist was selected from human C5a phage display libraries in which the C terminus of des-Arg74-hC5a was mutated. The selected molecule is a competitive C5a receptor antagonist in vitro and in vivo. Signal transduction is interrupted at the level of G-protein activation. In addition, the antagonist does not cause any C5a receptor phosphorylation. Proinflammatory properties su...