a functional treatment for skeletal damages in orthopedic and oral maxillofacial surgeries is required. platelet growth factors such as platelet derived growth factor (pdgf), bone morphogenic factor (bmp), transferring growth factor-β (tgf-β) and insulin-like growth factor-1 (igf-1) proceed wound healing and bone regeneration. in the present study we focused on the effect of platelet rich plasm...

Objective To determine seroprotection and vaccine response rates produced by a diphtheria–tetanus–acellular pertussis–inactivated poliovirus–Haemophilus influenzae type-b conjugate (DTaP–IPV//PRP~T) vaccine containing a polyribosyl-ribitol-phosphate (PRP)– tetanus toxoid conjugate (PentaximTM) and given with a hepatitis B vaccine. Methods In this multicentre open-label trial, 424 infants who re...

Citrate is the preferred anticoagulant for blood collection, as EDTA damages platelets and heparin modifies their function (1). Citrate allows the rapid generation of plateletrich plasma (PRP), with a high yield of platelets; however, this method has certain disadvantages. In particular, the PRP preparation has a limited stability (no longer than 2 h) and contains plasma proteins, including enz...

INTRODUCTION Bone defects are rather common after oral surgery and may prove difficult to repair. OBJECTIVE We provide a histomorphological analysis of the bone regenerative capacity of platelet-rich plasma at different concentrations and the extraction of platelet-rich bone marrow, compared with beta-tricalcium phosphate. METHODOLOGY We performed an experimental study on 8 pigs, in which w...

The routine use of haemophilus influenzae type b (Hib) vaccines has virtually eliminated Hib meningitis and other invasive Hib diseases in industrial countries [1]. The cost of the vaccine is considerable. In the United States of America the cost is approximately $5.60 per dose (1998 price: source, National Immunisation Program CDC) [1]. It has been suggested in Nature Medicine [2] that if deve...

Haemophilus influenzae is one of the microorganisms that make up the commensal flora of the upper respiratory tract. Carriage is common, but compatible with good health. None the less, H influenzae is a pathogen and, in the case of encapsulated type b organisms, causes life threatening, invasive (bacteraemic) infections, the most common and serious being meningitis and epiglottitis (table 1).' ...

Background. Autologous platelet-rich gel (APG) is an effective method to improve ulcer healing. However, the mechanisms are not clear. This study aimed to investigate the antibacterial effect of APG in vitro. Methods. Platelet-rich plasma (PRP), platelet-poor plasma (PPP) and APG were prepared from whole blood of sixteen diabetic patients with dermal ulcers. Antibacterial effects against Staphy...

Background Recently, the clinical use of low power lasers has increased, and it is said that wound healing is accelerated by their irradiation. The aim of this study was evaluation of the effect of platelet-rich plasma on proliferation and differentiation of human dental pulp stem cells with or without Ga-Al-As laser. Methods: In this experimental study, human lower third molar dental pulp c...