Polysorbates and Pluronic polymers are straightforward to use improve the performance of hydrophobic molecules, however, colloidal systems these not fully understood loading drug molecules in Polysorbate micelles rely on a plethora factors. Thus, it is laborious task select optimal as delivery vehicle. To pave way for Polysorbates, three with different hydrophobicity were selected oral Olanzapi...

Objective: To develop a stable composition with the substance of PEGylated interferon alfa-2b, to study technological and biopharmaceutical characteristics dosage form, conduct preclinical studies on chronic toxicity local irritating effect. Methods: Solid fats Witepsol® H15, W 35, Suppocire® BS2X, BM brands were used as suppository bases. Polysorbate 80 was an emulsifier. Citric acid, ascorbic...

Coenzyme Q10 (CoQ10) is an essential component in the electron-transport systems of mitochondria and bacteria and is often used as a supplementary treatment for some diseases. We previously reported that the bioavailability of CoQ10 powder was less than 10%. In this study, we investigated various preparations to improve the intestinal absorption of CoQ10 with focus on the effect of emulsificati...

DESCRIPTION LOPID (gemfibrozil tablets, USP) is a lipid regulating agent. It is available as tablets for oral administration. Each tablet contains 600 mg gemfibrozil. Each tablet also contains calcium stearate, NF; candelilla wax, FCC; microcrystalline cellulose, NF; hydroxypropyl cellulose, NF; hypromellose, USP; methylparaben, NF; Opaspray white; polyethylene glycol, NF; polysorbate 80, NF; p...

Several diseases and disorders are treatable with therapeutic proteins, but some of these products may induce an immune response, especially when administered as multiple doses over prolonged periods. Antibodies are created by classical immune reactions or by the breakdown of immune tolerance; the latter is characteristic of human homologue products. Many factors influence the immunogenicity of...

The synergistic effects of four sucrose substitutes, polysorbate and five artificial sweeteners were studied in vitro on growth pattern and acid production of seven glucose-grown Streptococcus mutans strains, representing the five serological groups after Bratthall. Four distinct growth patterns during glucose fermentation were observed: high rate of growth with low acid production, moderate gr...

The increasing prevalence of obesity has emerged as one of the most important global public health issue. The change to the human microbiome as a result of changes in the quality and quantity of food intake over the past several decades has been implicated in the development of obesity and metabolic syndrome. We administered polysorbate-80 to mice via gavage. The researchers monitor liver nonin...

I. The interfacial barrier controlled transport of some biologically important solutes in the aqueous polysorbate 80 hexadecane system were investigated by means of the multiparticulate dispersion technique. 2. It was shown that the resistances to transport of cholesterol, /3-sitosterol, desmosterol, 2oa-hydroxycholesterol, and vitamin D 3 across the oil/water interface, were of the order of IO...