نتایج جستجو برای: pore blocking model
تعداد نتایج: 2178899 فیلتر نتایج به سال:
Emergent rational drug design techniques explore individual properties of target biomolecules, small and macromolecule drug candidates, and the physical forces governing their interactions. In this minireview, we focus on the single-molecule biophysical studies of channel-forming bacterial toxins that suggest new approaches for their inhibition. We discuss several examples of blockage of bacter...
The gas slippage phenomenon under dry conditions has been investigated extensively both numerically and experimentally. However, very limited research focused on behavior wet conditions. Unlike conventional formation, the influence of water transport process cannot be neglected in tight formations due to comparable amount thin film attached along rock surface. It is found experimentally that fa...
pore network modeling uses a network of pores connected by throats to model the void space of a porous medium and tries to predict its various characteristics during multiphase flow of various fluids. in most cases, a non-realistic regular lattice of pores is used to model the characteristics of a porous medium. although some methodologies for extracting geologically realistic irregular network...
Two-pore domain potassium channels, like KCNK2, are known to play an important role in inflammatory diseases such as multiple sclerosis (MS). Upregulation of cellular adhesion molecules in mouse brain microvascular endothelial cells (MBMECs) of Kcnk2-/- mice resulted in elevated leukocyte trafficking into the central nervous system under inflammatory conditions. The current project aims to gain...
The suitability of three vapor deposition techniques for pore size modification was evaluated using polycarbonate track etched membranes as model supports. A feature scale model was employed to predict the pore geometry after modification and the resulting pure water flux. Physical vapor deposition (PVD) and pulsed plasma-enhanced chemical vapor deposition (PECVD), naturally, form asymmetric na...
A 20 amino acid synthetic peptide, corresponding to the amino-terminal region of the Shaker B (ShB) K+ channel and responsible for its fast inactivation, can block large conductance Ca(2+)-dependent K+ channels from rat brain and muscle. The ShB inactivation peptide produces two kinetically distinct blocking events in these channels. At lower concentrations, it produces short blocks, and at hig...
Extracellular Proton-Modulated Pore-Blocking Effect of the Anticonvulsant Felbamate on NMDA Channels
The physical properties of 3-D porous solids are defined by their molecular geometry. Hence, precise control of pore size, pore shape, and pore connectivity are needed to tailor them for specific applications. However, for porous molecular crystals, the modification of pore size by adding pore-blocking groups can also affect crystal packing in an unpredictable way. This precludes strategies ado...
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