Pseudoporphyria is a rare bullous dermatosis that clinically and histopathologically is similar to porphyria cutanea tarda. It mainly affects patients with chronic renal failure on peritoneal dialysis or hemodialysis. Medications can also be involved in the etiology. Diagnosis and management of this condition is a challenge for dermatologists. The authors report a case of pseudoporphyria relate...

Primary Care Trusts (PCTs) and Local Strategic Partnerships (LSPs) are being asked to assess local health inequalities in order to prioritize local action, to set local targets for reducing levels of health inequality locally and to demonstrate measurable progress. Despite this, little guidance has been provided on how to quantify health inequalities within PCTs and LSPs. This paper advocates t...

The isomeric composition of type-III heptacarboxylic porphyrinogens derived from decarboxylation of uroporphyrinogen III by erythrocyte uroporphyringogen decarboxylase was analysed by h.p.l.c. with electrochemical detection. All four possible isomers were identified, and there were little differences in the proportion of isomers formed by erythrocytes from normal subjects and from patients with...

reported to be as high as 69%.[1] Common cutaneous adverse effects include maculopapular eruptions and erythematous eruptions. Toxic epidermal necrolysis, Stevens–Johnson syndrome and acute generalized exanthematous pustulosis have also been reported with the use of imatinib. Other reported cutaneous adverse effects include: hypopigmentation, lichenoid reactions, pityriasiform eruptions, purpur...

Porphria cutanea tarda is characterized biochemically by excessive hepatic synthesis and urinary excretion of uroporphyrin I and 7-carboxylporphyrins. This pattern of excretion suggest an impaired ability to decarboxylate uroporphyrinogen to the paired ability to decarboxylate uroporphyringen to the 4-carboxyl porphyrinogen, coproporphyrinogen, a reaction catalyzed by the enzyme uroporphyringen...

BACKGROUND The Department of Health launched a national human papillomavirus immunisation programme for girls aged 12-13 years in September 2008. AIM To assess the feasibility and acceptability of implementing a school-based programme. METHOD HPV vaccination was offered over one academic year by two PCTs in 36 schools to 12-13-year-old girls, using different implementation plans. RESULTS ...

Excessive sun exposure may be associated with increased oxidative stress and oxidative damage of DNA. Based on this hypothesis, the authors focused on investigating the causal role of UV-induced genomic damage in the pathophysiology of porphyria cutaneatarda (photosensitive acquired metabolic disorder with autosomal dominanttransmittion). In this study we demonstrated that serum levels of 8-hyd...

We report two cases of porphyria cutanea tarda (PCT) positive for the antibody against hepatitis C virus (anti-HCV). The serological and histological examinations revealed that they were persistently infected with HCV and were suffering from liver disease compatible with chronic viral hepatitis. It is suggested that one of the factors which contribute to liver damage of patients with PCT may be...

Porphyria cutanea tarda (PCT) is the most frequent type of porphyria worldwide and results from a catalytic deficiency of uroporphyrinogen decarboxylase (UROD), the fifth enzyme in heme biosynthesis. At least two different types of PCT are currently distinguished: an acquired variant, also referred to as sporadic or type I PCT, in which the enzymatic deficiency is limited to the liver; and an a...

Correspondence: Giovanni Borroni, Clinica Dermatologica, IRCCS Policlinico S. Matteo, 27100 Pavia, Italy. Phone: international +39-0382-503494 – Fax. international +390382-526379. The term porphyria cutanea tarda (PCT) refers to a group of disorders biochemically charcaterized by reduced activity of uroporphyrinogen decarboxylase in liver and, in familial cases, in a number of tissues and cells...