BACKGROUND Polyglutamine (polyQ)-induced protein aggregation is the hallmark of a group of neurodegenerative diseases, including Huntington's disease. We hypothesized that a protease that could cleave polyQ stretches would intervene in the initial events leading to pathogenesis in these diseases. To prove this concept, we aimed to generate a protease possessing substrate specificity for polyQ s...

Three new sesquiterpene glycosides, possessing a rare aglycone with a sulfonyl between C-1 and C-15 positions, named 3-(3'E-7'R,8'-dihydroxy-4',8'-dimethyl-3'-nonenyl)-2,5-dihydro-1,1-dioxo-thiophen 7'-O-β-d-glucopyranosyl-(1→4)-O-β-d-glucopyranosyl-(1→4)-O-β-d-glucopyranoside (1), 3-(3'E-7'R,8'-dihydroxy-4',8'-dimethyl-3'-nonenyl)-2,5-dihydro-1,1-dioxo-thiophen 7'-O-β-d-glucopyranosyl-(1→4)-O-...

Chamomile (Matricaria chamomilla L.) is a widely used medicinal plant possessing several pharmacological effects due to presence of active compounds. In order to study of seed priming effects on seedling growth of chamomile, an experimental design, based on randomized complete design with three replications was conducted under greenhouse conditions in Research Institute of Forests and Rangeland...

Let a smooth family of Riemannian metrics g(τ) satisfy the backwards Ricci flow equation on a compact oriented n-dimensional manifold M . Suppose two families of normalized n-forms ω(τ) ≥ 0 and ω̃(τ) ≥ 0 satisfy the forwards (in τ) heat equation on M generated by the connection Laplacian ∆g(τ). If these n-forms represent two evolving distributions of particles over M , the minimum root-mean-squa...

This paper presents an approach enabling a smart card issuer to verify that a new applet securely interacts with already downloaded applets. A security policy has been de ned that associates levels to applet attributes and methods and de nes authorized ows between levels. We propose a technique based on model checking to verify that actual information ows between applets are authorized. We illu...

this study was conducted to investigate the type and origin of clay minerals via several profiles in lordegan hilly lands. the profiles were located in two kinds of land uses including forest and dry farm at different slope positions as sampling sites. the soil saples were collected from two depths of soil horizons to indicate cec, soil texture, oc%, calcium carbonate equivalent, x-ray diffract...

the recent increasing number of women in organizations has not been associated with their appropriate positions. therefore, potential capacity of half of active workforce is not utilized fully in managerial positions for organizational success. this study investigates why women are less likely to achieve higher positions in organizations .the study identifies barriers of women's access to ...