Synthetic ochre and amber tRNA suppressor genes derived from the yeast tRNA(PheGAA) sequence have been constructed. They were efficiently transcribed in vitro and expressed in vivo via a synthetic expression cassette. tRNA(PheUUA) and tRNA(PheUUA) delta IVS (IVS = intervening sequence) are relatively inefficient ochre suppressors. They are toxic to the cell when expressed on a multicopy plasmid...

BACKGROUND Left ventricular hypertrophy (LVH) is a powerful independent risk factor for cardiovascular morbidity and mortality among hypertensive patients. Data regarding relationships between diabetes and LVH are controversial and inconclusive, whereas possible gender differences were not specifically investigated. The goal of this work was to investigate whether gender differences in left hea...

BACKGROUND Ultrasonic tissue characterization (UTC) has been widely used to investigate left ventricular (LV) dysfunction in various cardiac disorders. The aim of this study was to investigate the correlation between functional capacity and UTC in patients with idiopathic dilated cardiomyopathy (IDCM). METHODS AND RESULTS Treadmill test according to modified-Bruce protocol was performed in 48...

Giriş ve Amaç: Adana, talasemi kuşağında yer alan açısından yüksek frekansa sahip bir şehirdir. Suriye’den ülkemize olan göçün yoğun kısmı Adana şehrine olmaktadır bunun sonucunda farklı tipte mutasyonları görülmeye başlanmıştır. Bu çalışmada, merkezimizde takip tedavi edilen beta majör tanılı Türkiyeli gelen hastaların globin gen mutasyon sonuçlarının değerlendirilmesi amaçlandı.
 Gereç Y...

* Associate Professor Department of Community, Occupational and Family Medicine National University of Singapore Address for Reprints: Dr Chia Kee Seng, Department of Community, Occupational and Family Medicine, National University of Singapore, Lower Kent Ridge Road, Singapore 119260. Introduction In modern medical research, it is rare to limit data analysis to merely two variables: a single e...

Sensitized T lymphocytes can mediate potent antitumor effects when transferred to tumor-bearing animals. Employing the MCA 105 and MCA 106 sarcomas, we were able to generate antitumor effector cells by immunization of syngeneic mice with tumor cells admixed with Corynebacterium parvum. These immune splenocytes could be further sensitized and expanded in culture by the in vitro sensitization (IV...

Polymorphisms in folate pathway genes may influence the susceptibility to acute lymphoblastic leukemia (ALL). DNA was isolated from 245 pediatric ALL patients (cases) and from 500 blood bank donors (controls). Polymorphisms in methylene-tetrahydrofolate reductase (MTHFR 677C>T, 1298A>C), methionine synthase (MTR 2756A>G), methionine synthase reductase (MTRR 66A>G), methylenetetrahydrofolate deh...

This paper shows that Py and Pypy are practically insecure. If one key is used with about 2 IVs with special differences, with high probability two identical keystreams will appear. This can be exploited in a key recovery attack. For example, for a 16-bye key and a 16-byte IV, 2 chosen IVs can reduce the effective key size to 3 bytes. For a 32-bye key and a 32-byte IV, the effective key size is...