The sodium and chloride retaining effect of suprarenal cortical extracts and of crystalline compounds derived from the suprarenal cortex parallels their effectiveness in maintaining suprarenalectomized dogs. All of the active compounds thus far studied produce a potassium diuresis when injected into normal dogs. The injection of a synthetic compound, desoxy-corticosterone acetate, produced in n...

Two alternative and complementary one-pot procedures for the direct transformation of 2-amino alcohols to N-tosyl aziridines are presented. The unsubstituted parent compound and its less hindered homologues can be obtained in high yields by tosylation and in situ cyclisation effected by potassium hydroxide in water/dichloromethane. Higher substituted amino alcohols give better yields using pota...

Thiophene substituted chalcones (1a-e) were cyclised with thiourea in presence of potassium hydroxide to get 4-substituted-6-(thiophen-2-yl)pyrimidine-2-thiols (2a-e) which were then stirred with methyl iodide to obtain 4-substituted-2-(methylsulfanyl)-6-(thiophen-2-yl)pyrimidines (3a-e). Compounds (3a-e) were refluxed with different N-methylpiperazine and N-phenylpiperazine to afford 4-substit...

Abstract A defect structure and osseointegration capacity of sodium chloride co-substituted hydroxyapatite (NaClAp) were newly studied. The NaClAp was prepared by reacting H 3 PO 4 Ca(OH) 2 with NaNO NH Cl followed sintering; pure (HAp) synthesized as a control. After sintering, the co-substitution Ca OH Na Cl, respectively, produced charged point defects at sites. Also, molecules partially ado...

Strontium (Sr) substituted calcium phosphate (CaP) coatings have stimulated a lot of interest as Sr is known to provide osteoconductive properties. Most the work date with respect has focused on creation crystalline Sr-substituted hydroxyapatite (HA), opposed amorphous coatings. The reported here utilises radio frequency magnetron sputtering deposit both CaP and Sr-containing their characterisa...

The synthesis of trifluoromethyl-substituted pyridylboronic acids and pyrazolylboronic esters is described via lithiation-boronation protocols (Schemes 1, 3 and 4). A study of their palladium-catalysed cross-couplings with heteroaryl halides is presented. CF3-substituted aryl/heteroaryl-pyridines are thereby obtained (51-98% yields). Analogous cross-couplings have yielded heteroaryl-3-(trifluor...

The deposition of thin films bioactive materials is the most common approach to improve bone bonding ability an implant surface. With this purpose, several wet and plasma assisted methods were proposed in scientific literature. In review, we considered obtained by nanosecond Pulsed Laser Deposition (PLD). Since hydroxyapatite (HA) has composition structure similar that mineral component bone, i...