Ondansetron is a serotonin 5HT3 antagonist; anti-emetic drug. Bitter taste of the ondansetron is a major problem in ensuring patient compliance. The study was designed to formulate tasteless complexes of ondansetron with ion exchange resin and evaluate molecular properties of drug complex. The drug-loading process was carried out using various resins and was optimized using different drug:resin...

MnO2 supported on graphene oxide (GO) made from different graphite materials has been synthesized and further investigated as electrode materials for supercapacitors. The structure and morphology of MnO2-GO nanocomposites are characterized by X-ray diffraction, X-ray photoemission spectroscopy, scanning electron microscopy, transmission electron microscopy, Raman spectroscopy, and Nitrogen adso...

This study is designed to test the hypothesis that docetaxel [Doc] containing oily core nanocapsules [NCs] could be successfully prepared with a high percentage encapsulation efficiency [EE%] and high drug loading. The oily core NCs were generated according to the emulsion solvent diffusion method using neutral Labrafac CC and poly(d, l-lactide) [PLA] as oily core and shell, respectively. The e...

Although the bactericidal effect of copper has been known for centuries, there is a current resurgence of interest in the use of this element as an antimicrobial agent. During this study the use of dendritic copper microparticles embedded in an alginate matrix as a rapid method for the deactivation of Escherichia coli ATCC 11775 was investigated. The copper/alginate produced a decrease in the m...

Solvent cast mucosal films with improved drug loading have been developed by combining carboxymethyl cellulose (CMC), sodium alginate (SA), and carrageenan (CAR) using paracetamol and amoxicillin as model drugs and glycerol (GLY) as plasticizer. Films were characterized using X-ray powder diffraction (XRPD), scanning electron microscopy (SEM), folding resilience, swelling capacity, mucoadhesivi...

Among the array of nanomaterials, carbon nanotubes have shown great potential as drug carriers in the field of nanomedicine, owing to their attractive physicochemical structure, which facilitates functionalization of therapeutic molecules onto their external walls or being encapsulated inside the tubes. The aim of this preliminary study was to formulate betulinic acid (BA), a poorly water-solub...

Dynamic pore collapse in porous materials is studied by analyzing the finite deformation of an elastic/viscoplastic spherical shell under impulsive pressure loading. Effects of dynamic loading rate, pore size, initial porosity, strain-rate sensitivity, strain hardening, thermal softening, and mass density of the matrix material on the pore collapse process are examined and results are compared ...

in this work, we report synthesis and characterization of bi2o3 nanoparticles loaded on mesoporous mcm-41 nanoparticles by a simple solid-state dispersion (ssd) method. monoclinic bismuth oxide nanoparticles were prepared by polyacrylamide gel method and used as loading materials on the prepared mesoporous mcm-41 as a supporting material. fourier transform infrared spectroscopy (ft-ir), x-ray p...

Abstract Isotropy in microstructure and mechanical properties remains a challenge for laser powder bed fusion (LPBF) processed materials due to the epitaxial growth rapid cooling LPBF. In this study, high-strength TiB 2 /Al-Cu composite with random texture was successfully fabricated by using pre-doped powder. A series of advanced characterisation techniques, including synchrotron X-ray tomogra...