نتایج جستجو برای: pramipexole
تعداد نتایج: 579 فیلتر نتایج به سال:
The antiparkinsonian ropinirole and pramipexole are D3 receptor- (D3R-) preferring dopaminergic (DA) agonists used as adjunctive therapeutics for the treatment resistant depression (TRD). While the exact antidepressant mechanism of action remains uncertain, a role for D3R in the restoration of impaired neuroplasticity occurring in TRD has been proposed. Since D3R agonists are highly expressed o...
Dopaminergic therapy has paradoxical effects on cognition in Parkinson's disease (PD) patients, with some functions worsened and others improved. The dopamine overdose hypothesis is proposed as an explanation for these opposing effects of medication taking into account the varying levels of dopamine within different brain regions in PD. The detrimental effects of medication on cognition have be...
The characterization of [3H]pramipexole binding to bovine striatal membranes is reported in full experimental detail. According to kinetic experiments, saturation and competition studies a single binding site can be selectively labeled which turned out to be the high affinity D2 receptor. Addition of GPP(NH)P resulted in almost complete loss of specific binding. The bovine D2 subtype shows high...
The present work deals with the development of a prolonged release matrix tablet readily soluble drug pramipexole. new excipient Kollidon SR (a mixture 80% polyvinyl acetate and 20% polyvinylpyrrolidone) hypromellose K15M were used as polymers to control from selected prototypes. Various polymer concentrations tested achieve stable pH independent pramipexole 0.26 mg over 24 hours; samples prepa...
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