Prevention of skin aging and its treatment is an emerging field for development of new formulations in cosmetics. Accordingly, plant extracts with antioxidant properties are beneficial cosmetic ingredients for this purpose. This study was aimed at developing a stable and easily manufactured emulgel including green tea extract and rose oil that is effective on the barrier function and hydration ...

The ideal design of an airplane should include built-in sensors that are pre-blended in the perfect aerodynamic shape. Each built-in sensor is expensive to blend in and requires continuous maintenance and data processing, so we would like to use as few sensors as possible. The ideal formulation of the corresponding optimization problem is, e.g., to minimize the average detection error for fault...

| The ideal design of an airplane should include built-in sensors that are pre-blended in the perfect aerodynamic shape. Each built-in sensor is expensive to blend in and requires continuous maintenance and data processing, so we would like to use as few sensors as possible. The ideal formulation of the corresponding optimization problem is, e.g., to minimize the average detection error for fau...

Financial derivatives commonly contain pre-mature termination clauses, which are embedded rights held by the holder or writer. Well known examples of these stopping rights include the early exercise right in American options, the callable right in callable securities and the prepayment right in mortgage loans. In this paper, we show how to model the mortgagor’s prepayment in mortgage loans and ...

Time and resource constraints necessitate increasingly early decisions to advance or halt pre-clinical drug discovery programs. Early discovery or ‘‘tool’’ compounds may be potent inhibitors of new targets, but all too often they exhibit poor pharmaceutical and pharmacokinetic properties that make early assessment of in vivo efficacy difficult. 1,3-Dicyclohexylurea, a potent and selective inhib...

BACKGROUND Orodispersible tablets or fast dissolving tablets dissolve or disintegrate immediately on the patients' tongue or buccal mucosa. This drug delivery system is suitable for drugs undergoing high first pass metabolism. It improves bioavailability, reduces dosing frequency, and thereby minimizes the side effects and also makes the dosage form more cost-effective. In this study, polysacch...

Objective: Investigation of in vitro/in vivo behaviour of fast-dissolving tablets containing solid dispersions of oxcarbazepine is the focus of the present research work. Methods: The effect of various hydrophilic polymers on the aqueous solubility of oxcarbazepine was studied. Polyethylene glycol 6000 carrier was selected and solid dispersions were prepared by various methods. A total of nine ...

SYN-004 (ribaxamase) delayed release drug product is a multi-particulate, hard capsule for oral delivery of a recombinant β-lactamase enzyme designed to degrade β-lactam antibiotics administered intravenously, and thus prevent colon dysbiosis. Here we describe the development of the SYN-004 enteric coated pellet formulation, which has been tested in multiple clinical trials. Since the SYN-004 d...

We applaud Musculoskeletal Physiotherapy Australia for the formulation of the new Pre-Manipulative guidelines. The new guidelines are a step forward from the previous protocol because they allow individual practitioners choice when making clinical decisions. The previous protocol proved to be legally challenging and further increased practitioners' fear of manipulating.

abstract                                                                               the new drug delivery systems have been developed, which can remain in the stomach for prolonged period of time. the effervescent floating tablet is one of these systems. iron deficiency anaemia is a common disease in the world. ferrous sulphate is the most common ferrous preparation used to treat and prevent...