Preeclampsia is a 2-stage disorder. Stage 1 is decreased placental perfusion and generates stage 2 of the disorder, the maternal syndrome characteristic of preeclampsia. How the 2 stages are linked has been a topic of intense investigation for many years. One candidate phenomenon, which includes many other suggested linkages, is oxidative stress. This hypothesis predicts that the administration...

Meta-analysis of randomized studies on the use of low-dose aspirin in women at high risk of preeclampsia (PE) has demonstrated that if treatment is initiated at ≤16 weeks' gestation, there is significant reduction in the risk of PE [relative risk (RR) 0.47, 95% confidence interval (CI) 0.36-0.62], fetal growth restriction (RR 0.46, 95% CI 0.33-0.64), preterm birth (RR 0.35, 95% CI 0.22-0.57) an...

OBJECTIVE To determine whether early administration of aspirin prevents severe and mild preeclampsia. STUDY DESIGN A systematic review and meta-analysis of randomized controlled trials were performed. Studies in which women were randomized at or before 16 weeks' gestation to low-dose aspirin versus placebo or no treatment were included. The outcomes of interest were severe preeclampsia and mi...

The purpose of this paper is to evaluate the effectiveness of low-dose aspirin in the prevention of preeclampsia in low-risk and high-risk women. We identified randomized clinical trials of the use of low-dose aspirin to prevent preeclampsia through the PUBMED search engine, and through the Cochran Library database. Twenty-two studies met our inclusion criteria, and were divided according to th...

DESCRIPTION The chest radiograph demonstrating cardiomegaly and severe widening of the mediastinum (figure 1) is from a 55-year-old lady who presented with several months of breathlessness. Her ECG revealed Mobtiz type II seconddegree heart block. A 2-year history of pruritus was noted. CT scan revealed mediastinal lymphadenopathy. Transthoracic ECG showed thickening of the atrial septum consis...

Background & Aim: Èfó Wòròwó (Solanecio biafrae) an important vegetable in Nigeria has many health benefits non-scientific claims in herbal practice. This work was designed to evaluate the traditional application of Èfó Wòròwó (Solanecio biafrae) to reduce weight and fats in pre-obesity. Experimental:31 pre-obese individuals (35-70 years...

Implementing change in organizational systems is challenging, and implementing a new psychotherapeutic approach is no different. A literature exists on issues in implementation across a wide range of domains (technological, healthcare, justice). However, little of it is utilized in endeavours to implement innovations in psychological treatments. This paper draws on the implementation literature...