Recent data indicate that multiple myeloma is consistently preceded by the precursor states of monoclonal gammopathy of undetermined significance (MGUS) and smoldering myeloma. Currently, multiple myeloma is a clinical diagnosis based on manifestations including hypercalcemia, renal failure, anemia, and bone lesions, whereas MGUS and smoldering myeloma are diagnosed based on laboratory abnormal...

It is widely known that very low frequency/low frequency (VLF/LF) radiation has been recorded prior to large earthquakes in several seismically active countries of the world. The networks employed detect this consist stationary transmitters and receivers. However, there are reported cases existing being unable any electromagnetic earthquakes. In study, we determined optimal arrangement a mobile...

Anthralin and some of its derivatives have implied antipsoriatic effect in clinical and pharmaceutical studies. Anthralin is synthesized by different strategies. In this work we report the synthesis of "OEHA" as a precursor of another biological active compound.

Amyloidprecursor protein (APP), a type I membrane protein, is physiologically processed by or -secretases that cleave APP N-terminal to the transmembrane region. Extracellular -cleavage of APP generates a large secreted N-terminal fragment, and a smaller cellular C-terminal fragment. Subsequent -secretase cleavage in the transmembrane region of the C-terminal fragment induces secretion of small...