An intelligent observer looks at the world and sees not only what is, but what is moving and what can be moved. In other words, the observer sees how the present state of the world can transform in the future. We propose a model that predicts future images by learning to represent the present state and its transformation given only a sequence of images. To do so, we introduce an architecture wi...

In this Editorial, the Chief Scientific Editor of Science Signaling predicts some of the emerging areas to watch for advances in signaling research in 2018.

We present an approach to sensorimotor control in immersive environments. Our approach utilizes a high-dimensional sensory stream and a lower-dimensional measurement stream. The cotemporal structure of these streams provides a rich supervisory signal, which enables training a sensorimotor control model by interacting with the environment. The model is trained using supervised learning technique...

On the face of it, memory, imagination, and prediction seem to be distinct cognitive functions. However, metacognitive, cognitive, neuropsychological, and neuroimaging evidence is emerging that they are not, suggesting intimate links in their underlying processes. Here, we explore these empirical findings and the evolving theoretical frameworks that seek to explain how a common neural system su...

The efficacy of bypass surgery in patients with ischemic cardiomyopathy remains impossible to forecast accurately. In particular, individual variability in factors such as disease comorbidities, genetic background, aging, disease progression, lifestyle, and medications makes the prediction of the outcome of bypass surgery a herculean task. Identifying readily available patient-specific informat...

76 The theme for the 142nd annual meeting of the American Fisheries Society (AFS) was “Fisheries Networks: Building Ecological, Social, and Professional Relationships,” and that provided me a hook to reflect on how studies of ecological networks have developed and how they can be used to inform fisheries research. Ecological networks, as we know them, date back to the pioneering studies of Raym...

When Orville Wright flew his airplane over a small stretch of rolling grassland in 1903, the managing editor of Scientific American predicted that thousands of planes would soon fly over every city, delivering patrons to theaters. On the eve of the First World War, two famous British aviators argued that planes would prevent wars in the future (because they brought people together). Scientists,...

Recent genome-wide association studies (GWAS) have identified many susceptibility loci for a variety of complex traits. There is intense interest in evaluating the potential utility of these variants for individualized risk prediction for chronic diseases such as breast cancer. A recent article in this journal (1) evaluated the potential discriminatory accuracy of breast cancer risk models that...

It is now well established that predictive models can be generated from the artifacts of software projects. So it is time to ask “what’s next?”. I suggest that predictive modeling tools can and should be refactored to address the near-term issue of decision systems and the long-term goal of social reasoning. INTRODUCTION: In software engineering (SE) there is much we are seeing, but little we a...