Serum FSH and LH levels in 104 patients with disorders of sexual development were determined by radioimmunoassay and compared with serum FSH and LH levels in 164 normal individuals.32 of 35 gonadal dysgenesis patients (ages 4.8-18.9 yr) had serum FSH levels which were elevated above the range of normal for chronological age, and 19 had serum LH levels similarly elevated. All patients with eleva...

INTRODUCTION We describe the etiology, MRI findings, and growth patterns in girls who had presented with signs of precocious puberty (PP), i.e., premature breast development or early menarche. Special attention was paid to the diagnostic findings in 6- to 8-year-olds. MATERIALS AND METHODS We reviewed the medical records of 149 girls (aged 0.7-10.3 years) who had been evaluated for PP in the ...

Background Premature adrenarche (PA) has been linked to early thelarche and menarche, but longitudinal data on growth and pubertal development after PA are insufficient. Methods Growth and pubertal development of mostly full-term and appropriate for gestational age-born 43 PA (36 girls) and 63 control children (52 girls) were analyzed prospectively. Children examined first at the mean age of ...

C lassically, the normal chronological age for pubertal onset is between 8 and 13 years in girls and 9 and 14 years in boys based on data from epidemiological studies from the 60’s (1). However, the age limit for pubertal timing is still a challenge (2,3). It is well known that puberty is a complex and multi factorial process that involves genetic, metabolic, socio economic, nutritional and eth...

BACKGROUND Declines in the onset age of secondary sexual development have been reported in a number of recent studies in western and Asian countries. A study of Hat-Yai school girls in 1994 in Thailand showed that the ages at thelarche and menarche were 9.9 and 12.4 years, respectively. This study was to determine whether there was a decline in the average age of puberty in Hat-Yai school girls...

Precocious puberty is defined as the development of secondary sexual characteristics before the age of 8 years in girls and 9 years in boys. Gonadotropin-dependent precocious puberty (GDPP) results from the premature activation of the hypothalamic-pituitary-gonadal axis and mimics the physiological pubertal development, although at an inadequate chronological age. Hormonal evaluation, mainly th...

Approximately 9 to 15% arachnoid cysts occur in the sellar or suprasellar region. The optimal management of symptomatic suprasellar cysts continues to pose a challenge to neurosurgeons. This case report describes a patient with a suprasellar arachnoid cyst who presented at the age of 3 and was followed for 20 years after cystoventriculostomy. A girl was referred to neurosurgery department by a ...

PURPOSE It is difficult to differentiate between central precocious puberty (CPP) and premature thelarche (PT) in girls. The aim of this study was to investigate the diagnostic usefulness of pelvic ultrasonography to distinguish between CPP and PT in girls with early breast development. METHODS This study included girls with early breast development who visited the clinic between January 2012...

OBJECTIVE Kisspeptin levels have been reported in children with premature thelarche, precocious puberty and adolescent gynecomastia, but there are no reports on kisspeptin levels in the neonatal period. This study aimed to investigate plasma kisspeptin hormone levels in newborns with and without breast enlargement. METHODS Plasma kisspeptin levels and other related biochemical variables were ...

Puberty is the period of transition from childhood to adulthood characterized by attainment adult height and body composition, accrual bone strength acquisition secondary sexual characteristics, psychosocial maturation reproductive capacity. In girls, menarche a late marker puberty. Primary amenorrhea defined as absence in ≥ 15-year-old females with developed characteristics normal growth or ≥1...