نتایج جستجو برای: preproinsulin

تعداد نتایج: 224  

Journal: :Cell metabolism 2007
Barton Wicksteed Yuji Uchizono Cristina Alarcon Jill F McCuaig Anath Shalev Christopher J Rhodes

Insulin production in pancreatic beta cells is predominantly regulated through glucose control of proinsulin translation. Previously, this was shown to require sequences within the untranslated regions (UTRs) of the preproinsulin (ppI) mRNA. Here, those sequences were found to be sufficient for specific glucose-regulated proinsulin translation. Furthermore, an element 40-48 bp from the 5' end o...

Journal: :Diabetes 2001
F Song M Srinivasan R Aalinkeel M S Patel

Four-day-old rat pups that are raised artificially on a high-carbohydrate (HC) milk formula immediately develop hyperinsulinemia, which persists into adulthood without any further nutritional stimulus. cDNA array analysis was used to identify large-scale changes in gene expression patterns in islets from 12- and 100-day-old HC rats in response to the HC dietary modification during the suckling ...

Journal: :Comparative biochemistry and physiology. Part A, Molecular & integrative physiology 2014
L H Sumners W Zhang X Zhao C F Honaker S Zhang M A Cline P B Siegel E R Gilbert

Artificial selection of White Plymouth Rock chickens for juvenile (day 56) body weight resulted in two divergent genetic lines: hypophagic low weight (LWS) chickens and hyperphagic obese high weight (HWS) chickens, with the latter more than 10-fold heavier than the former at selection age. A study was designed to investigate glucose regulation and pancreas physiology at selection age in LWS chi...

Journal: :The Journal of clinical investigation 1989
P J Whiteley J P Lake R F Selden J A Kapp

We have used transgenic mice to study immune tolerance to autologous, non-MHC encoded proteins that are expressed at physiological levels in the circulation. The transgenic mice used in these studies express the human preproinsulin gene and synthesize human proinsulin. Human and mouse insulin are secreted from the pancreatic islets of transgenic mice in response to normal physiological stimuli,...

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