OBJECTIVES The purposes of this study were to develop a pediatric-focused tool for adverse drug event detection and describe the incidence and characteristics of adverse drug events in children's hospitals identified by this tool. METHODS A pediatric-specific trigger tool for adverse drug event detection was developed and tested. Eighty patients from each site were randomly selected for retro...

BACKGROUND Data on the prevalence of adverse drug event (ADE)-related emergency department (ED) visits in developing countries are limited. Malaysia is located in South-East Asia, and, to our knowledge, no information exists on ADE-related ED visits. OBJECTIVE The objective of this study was to determine the prevalence, preventability, severity, and outcome of drug-related ED visits. METHOD...

OBJECTIVE To determine the incidence and types of preventable adverse events in elderly patients. DESIGN Review of random sample of medical records in two stage process by nurses and physicians to detect adverse events. Two study investigators then judged preventability. SETTING Hospitals in US states of Utah and Colorado, excluding psychiatric and Veterans Administration hospitals. SUBJE...

Background: The wide and indiscriminate use of drugs has increased the incidence and the modes of presentation of cutaneous drug reaction. Adverse cutaneous drug reactions are common, comprehensive information about their incidence, severity and ultimate health effects are unavailable. Objective: To study and evaluate incidence of adverse cutaneous drug reaction (ACDR) at our tertiary care hosp...

Usage of cancer chemotherapeutics drugs can be associated with adverse drug reactions. When IgE-mediated drug reactions are formed following administration of a chemotherapeutic drug that is a drug of choice, drug desensitization protocols can be helpful. Hypersensitivity reactions can be allergic or nonallergic, but the clinical manifestations are similar. Rapid drug desensitization (RDD) is e...

Introduction: Adverse reactions are the documented hazards of drug treatment and they can happen with any class drugs several studies exposed that incidence is increasing blood products.
 Objectives: The main aim this study to identify analyze Drug Reactions Hematinics in a tertiary care hospital.
 Methods: This prospective observational was conducted for period 6 months.
 Result...

BACKGROUND The objective of analysis of ADRs caused by drugs that pertain to the ATC group N (nervous system), as reported to the Croatian Agency for Medicinal Products and Medical Devices for the period from March 2005 to December 2008, was to examine the types of ADRs collected in said period, the profile of reporters and the possible impacts this could have on prescribing this group of medic...

Polymorphisms in the genes that code for drug-metabolising enzymes, drug transporters, drug receptors, and ion channels can affect an individual's risk of having an adverse drug reaction, or can alter the efficacy of drug treatment in that individual. Mutant alleles at a single gene locus are the best studied individual risk factors for adverse drug reactions, and include many genes coding for ...

Toxicology has two main goals in relation to adverse drug reactions (ADRs). The first is to identify and characterize the potential for harmful effects that can be produced in biological systems, particularly laboratory animals, by a drug, and to suggest therapeutic circumstances in which toxic responses may occur and/or are unlikely to occur. The second is necessary when unexpected adverse cli...